| Cell to cell interaction in the immune response. IV. Site of action of antilymphocyte globulin. | |
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MedLine Citation:
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PMID: 5691988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this series of papers it has been shown that the immune response of mice to sheep erythrocytes requires the participation of two classes of lymphoid cells. Thymus-derived cells initially react with antigen and then interact with another class of cells, the antibody-forming cell precursors, to cause their differentiation to antibody-forming cells. Antilymphocyte globulin depressed the ability of mice to respond to sheep erythrocytes. This effect was more marked when the antigen was injected intraperitoneally than intravenously, and occurred only when the antilymphocyte globulin was given before or simultaneously with antigen. Injection of thymus cells restored to near normal the ability to respond to an intravenous injection of sheep erythrocytes. Spleen cells from antilymphocyte globulin-treated mice gave a weak adoptive immune response in irradiated recipients. The addition of thymus cells however enabled a response similar to that given by normal spleen cells. When thymectomized irradiated recipients were used, normal spleen cells continued to give a higher response to a challenge of sheep erythrocytes at 2 and 4 wk postirradiation than did spleen cells from ALG-treated donors. This result is more consistent with the notion that thymus-derived target cells are eliminated, rather than temporarily inactivated, by antilymphocyte globulin. These findings suggest that, in vivo, antilymphocyte globulin acts selectively on the thymus-derived antigen-reactive cells. |
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Authors:
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W J Martin; J F Miller |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 128 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1968 Oct |
Date Detail:
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Created Date: 1968-10-28 Completed Date: 1968-10-28 Revised Date: 2010-09-13 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 855-74 Citation Subset: AIM; IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibody Formation / drug effects* Antigens Antilymphocyte Serum / pharmacology Binding Sites / drug effects* Chromium Isotopes Erythrocytes Hemolysin Proteins Immune Sera / pharmacology* Immunosuppressive Agents* Injections, Intraperitoneal Injections, Intravenous Lymphocytes* Mice Radiation Effects Sheep Spleen / cytology*, immunology Thymus Gland |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antilymphocyte Serum; 0/Chromium Isotopes; 0/Hemolysin Proteins; 0/Immune Sera; 0/Immunosuppressive Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1968 by The Rockefeller University Press Received Day: 3 Month: 6 Year: 1968 Print publication date: Day: 1 Month: 10 Year: 1968 Volume: 128 Issue: 4 First Page: 855 Last Page: 874 ID: 2138548 PubMed Id: 5691988 |
| CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE : IV. SITE OF ACTION OF ANTILYMPHOCYTE GLOBULIN | |
| W. J. Martin | |
| J. F. A. P. Miller | |
| From The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia |
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