Document Detail

Cell to cell interaction in the immune response. IV. Site of action of antilymphocyte globulin.
Jump to Full Text
MedLine Citation:
PMID:  5691988     Owner:  NLM     Status:  MEDLINE    
In this series of papers it has been shown that the immune response of mice to sheep erythrocytes requires the participation of two classes of lymphoid cells. Thymus-derived cells initially react with antigen and then interact with another class of cells, the antibody-forming cell precursors, to cause their differentiation to antibody-forming cells. Antilymphocyte globulin depressed the ability of mice to respond to sheep erythrocytes. This effect was more marked when the antigen was injected intraperitoneally than intravenously, and occurred only when the antilymphocyte globulin was given before or simultaneously with antigen. Injection of thymus cells restored to near normal the ability to respond to an intravenous injection of sheep erythrocytes. Spleen cells from antilymphocyte globulin-treated mice gave a weak adoptive immune response in irradiated recipients. The addition of thymus cells however enabled a response similar to that given by normal spleen cells. When thymectomized irradiated recipients were used, normal spleen cells continued to give a higher response to a challenge of sheep erythrocytes at 2 and 4 wk postirradiation than did spleen cells from ALG-treated donors. This result is more consistent with the notion that thymus-derived target cells are eliminated, rather than temporarily inactivated, by antilymphocyte globulin. These findings suggest that, in vivo, antilymphocyte globulin acts selectively on the thymus-derived antigen-reactive cells.
W J Martin; J F Miller
Related Documents :
416588 - Number of nucleoli in ehrlich tumor cells during interphase.
2930498 - Feedback regulation of s-adenosylmethionine decarboxylase synthesis.
3731108 - Cell surface sialomucin and resistance to natural cell-mediated cytotoxicity of rat mam...
2542448 - Esr studies of the interaction of copper(ii)ghk, histidine, and ehrlich cells.
11069768 - Supplementation of a mutant keratin by stable expression of desmin in cultured human eb...
816068 - Toxic effects of ricin: studies on the pathogenesis of liver lesions.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  128     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1968 Oct 
Date Detail:
Created Date:  1968-10-28     Completed Date:  1968-10-28     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  855-74     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antibody Formation / drug effects*
Antilymphocyte Serum / pharmacology
Binding Sites / drug effects*
Chromium Isotopes
Hemolysin Proteins
Immune Sera / pharmacology*
Immunosuppressive Agents*
Injections, Intraperitoneal
Injections, Intravenous
Radiation Effects
Spleen / cytology*,  immunology
Thymus Gland
Reg. No./Substance:
0/Antigens; 0/Antilymphocyte Serum; 0/Chromium Isotopes; 0/Hemolysin Proteins; 0/Immune Sera; 0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
Download PDF
Copyright © 1968 by The Rockefeller University Press
Received Day: 3 Month: 6 Year: 1968
Print publication date: Day: 1 Month: 10 Year: 1968
Volume: 128 Issue: 4
First Page: 855 Last Page: 874
ID: 2138548
PubMed Id: 5691988

W. J. Martin
J. F. A. P. Miller
From The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

Article Categories:
  • Article

Previous Document:  Cell to cell interaction in the immune response. 3. Chromosomal marker analysis of single antibody-f...
Next Document:  Induced pacemaker activity on toad skin.