| Cell-to-cell fusion, but not virus entry in macrophages by T-cell line tropic HIV-1 strains: a V3 loop-determined restriction. | |
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MedLine Citation:
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PMID: 7778305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T-cell lines chronically infected with laboratory adapted, T-cell tropic HIV-1 strains (RF, LAI, CBL-4, and NY5) induced syncytia after cocultivation with primary macrophages. Such fusion-competent strains, however, replicated inefficiently after cell-free infection of macrophage cultures. Evidence based on proviral DNA synthesis, pseudotype penetration, and a V3 loop mutation revealed that cell-free infection was restricted at a prepenetration stage in entry and controlled by envelope sequences. Our results suggest that primary macrophages are sensitive to cell-to-cell but not to virion-to-cell fusion induced by the envelope glycoproteins of several T-cell tropic HIV-1 strains. |
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Authors:
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G Simmons; A McKnight; Y Takeuchi; H Hoshino; P R Clapham |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Virology Volume: 209 ISSN: 0042-6822 ISO Abbreviation: Virology Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-07-11 Completed Date: 1995-07-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0110674 Medline TA: Virology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 696-700 Citation Subset: IM; X |
Affiliation:
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Virology Laboratory, Chester Beatty Laboratories, Institute of Cancer Research, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Communication Cell Fusion* Cell Line Cell-Free System Gene Products, env / chemistry, metabolism* Giant Cells / cytology HIV-1 / physiology* Humans Macrophages / cytology, physiology*, virology T-Lymphocytes / physiology*, virology Virion / physiology Virus Replication* |
| Chemical | |
Reg. No./Substance:
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0/Gene Products, env |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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