Document Detail


Cell-to-cell electrical interactions during early and late repolarization.
MedLine Citation:
PMID:  16686687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac electrical activity is significantly affected by variations in the conductance of gap junctions that connect myocytes to one another. To better understand how intrinsic (single cell) electrical activity is modulated by junctional conductance, we used a two-myocyte coupling system in which physically separate cells were electrically coupled via a variable resistance set by the investigator. This brief review summarizes our findings regarding: (1) the effect of the early phase of action potential repolarization (phase 1) and transient outward current (I(to)) on action potential conduction, and (2) the effect of coupling on the action potential plateau (late repolarization). We found that inhibition of I(to) markedly increased the ability of action potentials to propagate from cell-to-cell when junctional conductance was low. Electrically coupling two myocytes together also suppressed their beat-to-beat variability in action potential duration and contraction. Similarly, early afterdepolarizations (EADS) were readily suppressed by connecting a normal myocyte to one generating EADs. This high sensitivity of the plateau to variations in junctional interactions arises from the large increase in membrane resistance that occurs during this phase of the action potential.
Authors:
Kenneth W Spitzer; Andrew E Pollard; Lin Yang; Massimiliano Zaniboni; Jonathan M Cordeiro; Delilah J Huelsing
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  17 Suppl 1     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-11     Completed Date:  2006-10-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S8-S14     Citation Subset:  IM    
Affiliation:
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA. spitzer@cvrti.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Animals
Biological Clocks / physiology*
Cell Communication / physiology*
Cells, Cultured
Heart Conduction System / physiology*
Heart Ventricles / cytology
Humans
Membrane Potentials / physiology*
Myocytes, Cardiac / physiology*
Ventricular Function
Grant Support
ID/Acronym/Agency:
HL 52338/HL/NHLBI NIH HHS; HL 77607/HL/NHLBI NIH HHS; HL67961/HL/NHLBI NIH HHS; R37HL042873/HL/NHLBI NIH HHS

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