Document Detail

Cell-to-cell communication and vascular dementia.
MedLine Citation:
PMID:  22372561     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: VaD is the second-most common form of dementia, second only to that caused by AD. As the name indicates, VaD is predominantly considered a disease caused by vascular phenomena.
METHODS: In this invited review, we introduce the reader to recent developments in defining VaD as a unique form of dementia by reviewing the current pertinent literature. We discuss the clinical and experimental evidence that supports the notion that the microcirculation, specifically cell-to-cell communication, likely contributes to the development of VaD. Through exploration of the concept of the NVU, we elucidate the extensive cerebrovascular communication that exists and highlight models that may help test the contribution(s) of cell-to-cell communication at the microvascular level to the development and progression of VaD. Lastly, we explore the possibility that some dementia, generally considered to be purely neurodegenerative, may actually have a vascular component at the neurovascular level.
CONCLUSION: This latter recognition potentially broadens the critical involvement of microvascular events that contribute to the numerous dementias affecting an increasingly larger sector of the adult population.
Hans H Dietrich
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  19     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-10     Completed Date:  2012-11-13     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-7     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons Ltd.
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MeSH Terms
Cell Communication*
Dementia, Vascular / physiopathology*
Models, Cardiovascular*
Grant Support
R01 HL041250/HL/NHLBI NIH HHS; R01 HL041250-18/HL/NHLBI NIH HHS; R01 NS030555-13/NS/NINDS NIH HHS; R01HL57540/HL/NHLBI NIH HHS; R29 HL057540-04/HL/NHLBI NIH HHS

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