Document Detail


Cell therapy for type 2 diabetes: is it desirable and can we get it?
MedLine Citation:
PMID:  18834449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The functional mass of beta-cells is decreased in type 2 diabetes. Replacing missing beta-cells or triggering their regeneration may thus allow for improved treatment of type 2 diabetes, to the extent that this is combined with therapy for improved insulin sensitivity. Although progress has been made in deriving beta-cell-like cells from stem or precursor cells in vitro, these cannot yet be obtained in sufficient quantities or well enough differentiated to envisage their therapeutic use in beta-cell replacement therapy. Likewise, our very limited understanding of beta-cell regeneration in adult man does not yet allow for development of a valid strategy for kick-starting such a process in individuals with type 2 diabetes, whether by bona fide neogenesis or self-replication of existing beta-cells. Regardless of how beta-cell mass is restored in type 2 diabetes, it will be important to prevent any renewed decrease thereafter. Current understanding suggests that islet inflammation as well as signals from (insulin-resistant/inflamed) adipose tissue and skeletal muscle contribute towards decreased beta-cell mass in type 2 diabetes. It will likely be important to protect newly formed or implanted beta-cells from these negative influences to ensure their long-term survival.
Authors:
P A Halban
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Diabetes, obesity & metabolism     Volume:  10 Suppl 4     ISSN:  1463-1326     ISO Abbreviation:  Diabetes Obes Metab     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2008-12-09     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  100883645     Medline TA:  Diabetes Obes Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Affiliation:
Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland. philippe.halban@medecine.unige.ch
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Type 2 / physiopathology,  therapy*
Female
History, 18th Century
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Insulin Resistance / physiology*
Islets of Langerhans / cytology*,  physiology
Male
Stem Cell Transplantation / methods*,  trends
Tissue Therapy / methods*,  trends

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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