| Cell therapy for secondary osteonecrosis of the femoral condyles using the Cellect DBM System: a preliminary report. | |
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MedLine Citation:
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PMID: 18534437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a novel treatment of secondary osteonecrosis (ON) of the femoral condyles that is relatively simple, has low morbidity, and does not preclude the patient from other more extensive treatments in the event of failure. Three patients with extensive secondary ON of the femoral condyles were treated with decompression and debridement of the area of ON and grafting with the Cellect DBM System (Depuy Spine, Inc., Raynham, Mass), which provided a graft matrix enriched with a 3-fold to 4-fold increase in osteoprogenitor cells. At 2 years, all 3 patients had no complications and had excellent results with near-normal function and activity levels. Our preliminary results demonstrate that this technique is a viable option, at least in the short term, especially in patients with extensive, multifocal lesions. |
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Authors:
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Kevin Lee; Stuart B Goodman |
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Publication Detail:
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Type: Journal Article Date: 2008-03-28 |
Journal Detail:
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Title: The Journal of arthroplasty Volume: 24 ISSN: 1532-8406 ISO Abbreviation: J Arthroplasty Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-22 Completed Date: 2009-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703515 Medline TA: J Arthroplasty Country: United States |
Other Details:
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Languages: eng Pagination: 43-8 Citation Subset: IM |
Affiliation:
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National University Hospital of Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Bone Demineralization Technique / methods* Bone Regeneration / physiology Bone Transplantation / methods Debridement / methods Decompression, Surgical / methods Femur / pathology*, radiography Humans Knee Joint / pathology, radiography Mesenchymal Stem Cells / cytology, physiology Osteonecrosis / pathology*, therapy* Tissue Therapy / methods* Treatment Outcome Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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