Document Detail

Cell therapy for secondary osteonecrosis of the femoral condyles using the Cellect DBM System: a preliminary report.
MedLine Citation:
PMID:  18534437     Owner:  NLM     Status:  MEDLINE    
We describe a novel treatment of secondary osteonecrosis (ON) of the femoral condyles that is relatively simple, has low morbidity, and does not preclude the patient from other more extensive treatments in the event of failure. Three patients with extensive secondary ON of the femoral condyles were treated with decompression and debridement of the area of ON and grafting with the Cellect DBM System (Depuy Spine, Inc., Raynham, Mass), which provided a graft matrix enriched with a 3-fold to 4-fold increase in osteoprogenitor cells. At 2 years, all 3 patients had no complications and had excellent results with near-normal function and activity levels. Our preliminary results demonstrate that this technique is a viable option, at least in the short term, especially in patients with extensive, multifocal lesions.
Kevin Lee; Stuart B Goodman
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Publication Detail:
Type:  Journal Article     Date:  2008-03-28
Journal Detail:
Title:  The Journal of arthroplasty     Volume:  24     ISSN:  1532-8406     ISO Abbreviation:  J Arthroplasty     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-04-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703515     Medline TA:  J Arthroplasty     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
National University Hospital of Singapore.
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MeSH Terms
Bone Demineralization Technique / methods*
Bone Regeneration / physiology
Bone Transplantation / methods
Debridement / methods
Decompression, Surgical / methods
Femur / pathology*,  radiography
Knee Joint / pathology,  radiography
Mesenchymal Stem Cells / cytology,  physiology
Osteonecrosis / pathology*,  therapy*
Tissue Therapy / methods*
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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