Document Detail


Cell therapy in myocardial infarction: emphasis on the role of MRI.
MedLine Citation:
PMID:  17922278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Despite tremendous progress in myocardial infarct (MI) treatment, mortality rates remain substantial. Permanent loss of cardiomyocytes after ischemic injury, results in irreversible loss of myocardial contractility, reduction in ventricular performance, and may initiate the development of dilated heart failure. The discovery that pluripotent progenitor cells bear the capacity to differentiate to mature cardiac cells raised the hope of cell-based regenerative medicine. Engraftment of stem cells in the damaged myocardium, repair and functional improvement appeared suddenly a nearby reality. Promising results in animal models, and preliminary studies reporting the feasibility and safety of adult stem cell therapy in MI patients led to the first double-blinded randomized, placebo-controlled trials. The initial great enthusiasm for this paradigm shift in MI treatment has been tempered by the mainly negative or modestly positive study findings. Before new, larger clinical trials can be initiated, a number of critical questions and issues need to be considered starting with a scrutinized analysis of currently available data to extending our knowledge of the mechanism of scarless myocardial regeneration. Cardiac cell therapy necessitates a multidisciplinary approach, whereby imaging, in particular MRI, and the input of the imaging specialist is crucial to the success of cardiac cell regenerative medicine. MRI is an appealing technique for cell trafficking depicting engraftment, differentiation and survival. Endomyocardial cell administration can be achieved safely with MR fluoroscopy and MRI is without any doubt the most accurate and reproducible technique to measure study end-points.
Authors:
Yuxiang Ye; Jan Bogaert
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-10-09
Journal Detail:
Title:  European radiology     Volume:  18     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-11     Completed Date:  2008-06-10     Revised Date:  2008-06-17    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  548-69     Citation Subset:  IM    
Affiliation:
Department of Radiology, University Hospital K.U.L., Herestraat 49, 3000 Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement / physiology
Humans
Magnetic Resonance Imaging / methods*
Myocardial Infarction / therapy*
Randomized Controlled Trials as Topic
Stem Cell Transplantation*
Comments/Corrections
Erratum In:
Eur Radiol. 2008 May;18(5):955-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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