Document Detail

Cell swelling-induced peptide hormone secretion.
MedLine Citation:
PMID:  18727251     Owner:  NLM     Status:  MEDLINE    
Cell volume changes induced in various ways (anisosmotic environment, hormones, oxidative stress, substrate uptake) are an integral part of a signal transduction network regulating cell function. Cell swelling has received increasing attention as a stimulus for a variety of intracellular phenomena. One of the most remarkable effects of cell swelling is its powerful effect in inducing exocytosis of material in intracellular secretory vesicles. Secretion of essentially all so-packaged hormones including those from hypothalamus (thyrotropin-releasing hormone, TRH; gonadotropin-releasing hormone, GnRH), pituitary (LH, FSH, ACTH, MSH, TSH, prolactin, beta endorphin), pancreas (insulin, somatostatin, glucagon), heart (atrial natriuretic hormone) and kidney (renin) are stimulated in a concentration-related manner by medium hyposmolarity or isosmolar medium containing permeant molecules such as ethanol or urea (reviewed in Ref. 21). Cell swelling-induced exocytosis is not restricted to endocrine cells and hormones; medium hyposmolarity also induces secretion of exocrine pancreatic enzymes and myeloperoxidase from human polymorphonuclear leukocytes.
Vladimir Strbák; Julius Benicky; Susan E Greer; Zuzana Bacova; Miroslava Najvirtova; Monte A Greer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  559     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2004  
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-30     Citation Subset:  IM    
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava 83306, Slovakia.
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MeSH Terms
Cell Size*
Oxytocin / secretion
Peptide Hormones / secretion*
Pituitary Gland / cytology,  secretion
Prolactin / secretion
Thyrotropin-Releasing Hormone / secretion
Reg. No./Substance:
0/Peptide Hormones; 24305-27-9/Thyrotropin-Releasing Hormone; 50-56-6/Oxytocin; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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