Document Detail

Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors.
MedLine Citation:
PMID:  16580739     Owner:  NLM     Status:  MEDLINE    
Recent data have provided important clues about the molecular mechanisms underlying certain retinal degenerative diseases, including retinitis pigmentosa and age-related macular degeneration. Photoreceptor cell degeneration is a feature common to these diseases, and the death of these cells in many instances seems to involve the closely associated retinal pigment epithelial (RPE) cells. Under normal circumstances, both cell types are subject to potentially damaging stimuli (e.g. sunlight and high oxygen tension). However, the mechanism or mechanisms by which homeostasis is maintained in this part of the eye, which is crucial for sight, are an unsolved riddle. The omega-3 fatty acid family member docosahexaenoic acid (DHA), which is enriched in these cells, is the precursor of neuroprotectin D1 (NPD1). NPD1 inhibits oxidative-stress-mediated proinflammatory gene induction and apoptosis, and consequently promotes RPE cell survival. This enhanced understanding of the molecular basis of endogenous anti-inflammatory and neuroprotective signaling in the RPE presents an opportunity for the development of therapies for retinal degenerative diseases.
Nicolas G Bazan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2006-04-03
Journal Detail:
Title:  Trends in neurosciences     Volume:  29     ISSN:  0166-2236     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-07-25     Revised Date:  2013-05-13    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  IM    
LSU Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine in New Orleans, LA 70112, USA.
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MeSH Terms
Cell Death / physiology
Cell Survival / physiology
Docosahexaenoic Acids / metabolism*
Nerve Degeneration / metabolism
Oxidative Stress
Photoreceptor Cells / cytology,  metabolism*
Pigment Epithelium of Eye / cytology,  metabolism*
Retinal Degeneration / metabolism
Signal Transduction* / physiology
Grant Support
Reg. No./Substance:
0/protectin D1; 25167-62-8/Docosahexaenoic Acids

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