| Cell surface oligosaccharide modulation during differentiation: IV. Normal and transformed cell growth control. | |
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MedLine Citation:
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PMID: 3144638 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In previous studies it was shown that cell surface oligosaccharide affinity class distributions and binding capacities were down-regulated as normal cells approach senescence. Using a sensitive, amplified, lectin/specific-ligand competition analysis three other growth regulation states were compared to that of cellular senescence. Non-senescent and senescent low-density and contact-induced growth inhibition was compared with neoplastic cell growth control. Non-senescent human fetal lung fibroblasts (IMR-90) down-regulated their mannosyl and galactosyl specificities in response to both low-density and contact-induced growth inhibition. Senescent IMR-90 down-regulate their mannosyl residues in response to contact conditions while they up-regulate their galactosyl residues under the same conditions. Growth-transformed transplantable canine glioma cells did not show density-dependent regulation of their cell surface oligosaccharide structures. Modulation of the CG cells with a specific alpha-mannosidase II inhibitor, Ricinus communis a galactosyl specific lectin, and pokeweed mitogen a cellular differentiating agent resulted in an altered growth phenotype and up-regulation of the mannosyl and galactosyl surface oligosaccharides. These data indicate a controller function for the cell surface oligosaccharides and a general influence on growth control. |
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Authors:
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P L Mann; C M Swartz; D T Holmes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 44 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1989-02-09 Completed Date: 1989-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 17-33 Citation Subset: IM |
Affiliation:
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Department of Anatomy, University of New Mexico, School of Medicine, Albuquerque 87131. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaloids
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pharmacology Binding, Competitive Cell Differentiation* Cell Division / drug effects Cell Line Cell Membrane / ultrastructure* Cell Transformation, Neoplastic* Humans Lectins Oligosaccharides / analysis* Swainsonine |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Lectins; 0/Oligosaccharides; 72741-87-8/Swainsonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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