Document Detail


Cell surface heparan sulfate proteoglycan and the neoplastic phenotype.
MedLine Citation:
PMID:  2968986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell surface proteoglycans are strategically positioned to regulate interactions between cells and their surrounding environment. Such interactions play key roles in several biological processes, such as cell recognition, adhesion, migration, and growth. These biological functions are in turn necessary for the maintenance of differentiated phenotype and for normal and neoplastic development. There is ample evidence that a special type of proteoglycan bearing heparan sulfate side chains is localized at the cell surface in a variety of epithelial and mesenchymal cells. This molecule exhibits selective patterns of reactivity with various constituents of the extracellular matrix and plasma membrane, and can act as growth modulator or as a receptor. Certainly, during cell division, membrane constituents undergo profound rearrangement, and proteoglycans may be intimately involved in such processes. The present work will focus on recent advances in our understanding of these complex macromolecules and will attempt to elucidate the biosynthesis, the structural diversity, the modes of cell surface association, and the turnover of heparan sulfate proteoglycans in various cell systems. It will then review the multiple proposed roles of this molecule, with particular emphasis on the binding properties and the interactions with various intracellular and extracellular elements. Finally, it will focus on the alterations associated with the neoplastic phenotype and will discuss the possible consequences that heparan sulfate may have on the growth of normal and transformed cells.
Authors:
R V Iozzo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  37     ISSN:  0730-2312     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-08-23     Completed Date:  1988-08-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  61-78     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104.
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MeSH Terms
Descriptor/Qualifier:
Cell Communication
Cell Division
Cell Transformation, Neoplastic
Cytoskeleton / metabolism
Glycosaminoglycans / metabolism*
Heparan Sulfate Proteoglycans
Heparitin Sulfate / metabolism*,  physiology
Humans
Membrane Glycoproteins / metabolism*,  physiology
Phenotype
Proteochondroitin Sulfates / metabolism*,  physiology
Proteoglycans / metabolism*
Grant Support
ID/Acronym/Agency:
CA-39481/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 0/Heparan Sulfate Proteoglycans; 0/Membrane Glycoproteins; 0/Proteochondroitin Sulfates; 0/Proteoglycans; 9050-30-0/Heparitin Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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