| Cell-specific integration of artificial organelles based on functionalized polymer vesicles. | |
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MedLine Citation:
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PMID: 18444692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell organelles are subcellular structures characterized by specific functionalities. They often consist of membrane-delineated microcompartments with a unique set of enzymes. Here we report the design of synthetic organelles based on nanometer-sized polymer vesicles, show their introduction into cells in a target-specific fashion, document their intact biochemical functionality in the cellular environment, and study their intracellular trafficking. This novel paradigm of introducing polymer-based artificial organelles to specific target cells for expansion of their biochemical capabilities appears suited for biomedical applications such as enzyme replacement in genetic diseases or, more generically, to add a desired biochemical function to a cell. |
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Authors:
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Nadav Ben-Haim; Pavel Broz; Stephan Marsch; Wolfgang Meier; Patrick Hunziker |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-30 |
Journal Detail:
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Title: Nano letters Volume: 8 ISSN: 1530-6984 ISO Abbreviation: Nano Lett. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-14 Completed Date: 2008-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088070 Medline TA: Nano Lett Country: United States |
Other Details:
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Languages: eng Pagination: 1368-73 Citation Subset: IM |
Affiliation:
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Medical Intensive Care Unit, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomimetic Materials / chemistry* Humans Materials Testing Nanostructures / chemistry, ultrastructure Polymers / chemistry* Subcellular Fractions / chemistry*, ultrastructure* Unilamellar Liposomes / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Polymers; 0/Unilamellar Liposomes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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