| Cell-specific cytotoxicity of dextran-stabilized magnetite nanoparticles. | |
| | |
MedLine Citation:
|
PMID: 20427159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cytotoxicity of dextran-hybridized magnetite nanoparticles which were prepared by a novel polyol method was evaluated by incubation with four different kinds of cells, including rat liver cells BRL 3A, renal cells NRK, astrocyte and periphery blood mononuclear cells (PBMC). The study was designed not only to evaluate their cytotoxicity but also to reflect the interaction between nanoparticles and related cells in their circulation processes. By fluorescent-activated cell sorting technique, it was found that the cytotoxicity of the nanoparticles is cell-specific. Under the concentrations in our study (0-128 mg/mL), the nanoparticles lead to the apoptosis of PBMC in a concentration-dependant manner, but have almost no influence on the other kinds of cells. TEM images demonstrate that the nanoparticles were endocytosed by BRL 3A, NRK and astrocyte, and result in the apoptosis of PBMC without the observation of the uptaking process. The results suggest that the related cells in nanoparticles cycling process should also be concerned for the cytotoxicity evaluation. |
| | |
Authors:
|
Jing Ding; Ke Tao; Jiyu Li; Sheng Song; Kang Sun |
Related Documents
:
|
21504019 - Spatial and temporal dependence of the cerebral endothelial cells elasticity. 16701969 - The combined use of human neural and liver cell lines and mouse hepatocytes improves th... 10628369 - Epidermal growth factor receptor-dependent cytotoxic effect of anti-egfr antibody-ribon... 6895609 - Lethal activity and kinetic response of cultured human cells to 4'-(9-acridinylamino)me... 20063369 - Assessing nanotoxicity in cells in vitro. 21432609 - Effects of methylphenidate: the cellular point of view. 9463579 - Peripheral primitive neuroectodermal tumour with ganglioneuroma-like areas arising in t... 11205889 - Evidence of prooxidant and antioxidant action of melatonin on human liver cell line hepg2. 23646279 - Molecular and genetic advances in the regeneration of the intervertebral disc. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-08 |
Journal Detail:
|
Title: Colloids and surfaces. B, Biointerfaces Volume: 79 ISSN: 1873-4367 ISO Abbreviation: Colloids Surf B Biointerfaces Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-05-24 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9315133 Medline TA: Colloids Surf B Biointerfaces Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 184-90 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis / drug effects* Astrocytes / cytology, drug effects Cell Line Cells, Cultured Dextrans / chemistry* Dose-Response Relationship, Drug Ferrosoferric Oxide / chemistry, toxicity* Flow Cytometry Leukocytes, Mononuclear / cytology, drug effects Metal Nanoparticles / chemistry, toxicity, ultrastructure Microscopy, Electron, Transmission Rats Rats, Sprague-Dawley X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
|
1317-61-9/Ferrosoferric Oxide; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition dysfunction in depression: Event-related potentials during negative affective priming.
Next Document: Doxorubicin-incorporated nanoparticles composed of poly(ethylene glycol)-grafted carboxymethyl chito...