| Cell-specific activation of aflatoxin B1 correlates with presence of some cytochrome P450 enzymes in olfactory and respiratory tissues in horse. | |
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MedLine Citation:
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PMID: 12726741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Horses may be exposed to aflatoxin B(1) (AFB(1)) via inhalation of mouldy dust, leading to high exposure of olfactory and respiratory tissues. In the present study the metabolic activation of AFB(1) was examined in olfactory and respiratory tissues in horse. The results showed covalent binding of AFB(1)-metabolites in sustentacular cells and cells of Bowman's glands in the olfactory mucosa, in some cells of the surface epithelium of nasal respiratory, tracheal, bronchial and bronchiolar mucosa and in some glands in these areas. Immunohistochemistry revealed that cells expressing proteins reacting with CYP 3A4- and CYP 2A6/2B6-antibodies had a similar distribution as those having capacity to activate AFB(1). Our data indicate that the cell-specific activation of AFB(1) correlates with presence of some CYP-enzymes in olfactory and respiratory tissues in horse. |
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Authors:
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P Larsson; E Persson; E Tydén; H Tjälve |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research in veterinary science Volume: 74 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-02 Completed Date: 2003-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: England |
Other Details:
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Languages: eng Pagination: 227-33 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Biomedicum, Box 573, S-751 23 Uppsala, Sweden. pia.larsson@farmtox.slu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxin B1
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pharmacokinetics* Animals Aryl Hydrocarbon Hydroxylases / metabolism Biotransformation Cytochrome P-450 Enzyme System / metabolism Enzyme Inhibitors / pharmacology Female Flavanones* Flavonoids / pharmacology Glutathione / metabolism Horse Diseases / enzymology, metabolism* Horses Immunohistochemistry / veterinary Liver / enzymology Lung / enzymology Male Metyrapone / pharmacology Microsomes / enzymology Mixed Function Oxygenases / metabolism Olfactory Mucosa / enzymology* Respiratory Mucosa / enzymology* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Flavanones; 0/Flavonoids; 1162-65-8/Aflatoxin B1; 480-41-1/naringenin; 54-36-4/Metyrapone; 70-18-8/Glutathione; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Mixed Function Oxygenases; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/CYP3A protein, human; EC 1.14.14.1/coumarin 7-hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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