Document Detail


Cell sorting in development.
MedLine Citation:
PMID:  21501752     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
During the development of multicellular organisms, cell fate specification is followed by the sorting of different cell types into distinct domains from where the different tissues and organs are formed. Cell sorting involves both the segregation of a mixed population of cells with different fates and properties into distinct domains, and the active maintenance of their segregated state. Because of its biological importance and apparent resemblance to fluid segregation in physics, cell sorting was extensively studied by both biologists and physicists over the last decades. Different theories were developed that try to explain cell sorting on the basis of the physical properties of the constituent cells. However, only recently the molecular and cellular mechanisms that control the physical properties driving cell sorting, have begun to be unraveled. In this review, we will provide an overview of different cell-sorting processes in development and discuss how these processes can be explained by the different sorting theories, and how these theories in turn can be connected to the molecular and cellular mechanisms driving these processes.
Authors:
S F Gabby Krens; Carl-Philipp Heisenberg
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current topics in developmental biology     Volume:  95     ISSN:  1557-8933     ISO Abbreviation:  Curr. Top. Dev. Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0163114     Medline TA:  Curr Top Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  189-213     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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