Document Detail


Cell signaling pathways in Paracoccidioides brasiliensis--inferred from comparisons with other fungi.
MedLine Citation:
PMID:  16110443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human fungal pathogen Paracoccidioides brasiliensis is an ascomycete that displays a temperature-dependent dimorphic transition, appearing as a mycelium at 22 degrees C and as a yeast at 37 degrees C, this latter being the virulent form. We report on the in silico search made of the P. brasiliensis transcriptome-expressed sequence tag database for components of signaling pathways previously known to be involved in morphogenesis and virulence in other species of fungi, including Saccharomyces cerevisiae, Cryptococcus neoformans, Candida albicans, and Aspergillus fumigatus. Using this approach, it was possible to identify several protein cascades in P. brasiliensis, such as i) mitogen-activated protein kinase signaling for cell integrity, cell wall construction, pheromone/mating, and osmo-regulation, ii) the cAMP/PKA system, which regulates fungal development and virulence, iii) the Ras protein, which allows cross-talking between cascades, iv) calcium-calmodulin-calcineurin, which controls cell survival under oxidative stress, high temperature, and membrane/cell wall perturbation, and v) the target of rapamycin pathway, controlling cell growth and proliferation. The ways in which P. brasiliensis responds to the environment and modulates the expression of genes required for its survival and virulence can be inferred through comparison with other fungi for which this type of data is already available.
Authors:
Larissa Fernandes; Marcus A M Araújo; André Amaral; Viviane Castelo Branco Reis; Natália F Martins; M S Felipe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-30
Journal Detail:
Title:  Genetics and molecular research : GMR     Volume:  4     ISSN:  1676-5680     ISO Abbreviation:  Genet. Mol. Res.     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-19     Completed Date:  2006-04-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101169387     Medline TA:  Genet Mol Res     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  216-31     Citation Subset:  IM    
Affiliation:
Departamento de Biologia Celular, IB, Universidade de Brasília, Brasília, DF, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Cyclic AMP-Dependent Protein Kinases / metabolism
Expressed Sequence Tags*
Fungal Proteins / metabolism*
Fungi / cytology,  metabolism,  pathogenicity
Humans
Mitogen-Activated Protein Kinases / metabolism
Osmosis / physiology
Paracoccidioides / metabolism,  pathogenicity,  physiology*
Pheromones / metabolism
Sequence Alignment
Signal Transduction / genetics*,  physiology
Transcription, Genetic*
ras Proteins / metabolism
Chemical
Reg. No./Substance:
0/Fungal Proteins; 0/Pheromones; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 3.6.5.2/ras Proteins

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