Document Detail

Cell shape changes induced by sulphate in the Cloudman mouse melanoma cell line.
MedLine Citation:
PMID:  8473569     Owner:  NLM     Status:  MEDLINE    
The mechanism of cell shape changes and haematogenous translocations (metastases) in mouse malignant melanoma cells induced by phorbol esters and protein kinase C (PKC) is reported as adhesion "downregulation", exocytosis and motility. However, PKC activation also produces intracellular alkalinization, a causal factor in plasma membrane internalization, cell rounding and detachment that does not necessarily implicate specific cell adhesion downregulation. We show here that Cloudman mouse malignant melanoma cells can be induced to round up and detach with concomitant intracellular alkalinization by simple inorganic sulphate treatment, thereby suggesting an alternative explanation to the reported phenomena.
B H Bay; K H Sit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  108     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-05-17     Completed Date:  1993-05-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Department of Anatomy, National University of Singapore, Kent Ridge.
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MeSH Terms
Cell Size / drug effects
Melanoma, Experimental / pathology*,  ultrastructure
Microscopy, Electron, Scanning
Sulfates / pharmacology*
Tumor Cells, Cultured
Reg. No./Substance:

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