Document Detail

Cell senescence: hypertrophic arrest beyond the restriction point.
MedLine Citation:
PMID:  17001692     Owner:  NLM     Status:  MEDLINE    
Withdrawal of mitogens (growth factors) arrests normal cells in G0 (quiescence). All other stresses and factors arrest cell cycle beyond the restriction point in G1 and G2 (non-G0 arrest), in the presence of mitogenic stimulation. Strong mitogenic stimuli by themselves cause non-G0 arrest. Unlike G0, arrest beyond restriction point is characterized by both high levels of cyclins and CDK inhibitors, activated mitogenic pathways with a secondary GF resistance, and continuous mass growth (cell hypertrophy). Prolonged hypertrophic arrest culminates in cell senescence. This review discusses that quiescence and senescence are two opposite, mutually exclusive conditions and that cell senescence can be reversed and prevented.
Mikhail V Blagosklonny
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  209     ISSN:  0021-9541     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2007-02-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  592-7     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley-Liss, Inc.
Cancer Center, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA.
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MeSH Terms
Aging / physiology
CDC2 Protein Kinase / metabolism
Cell Aging / physiology*
Cell Cycle / physiology*
DNA Damage
Life Expectancy
Mitogens / metabolism
Saccharomyces cerevisiae / genetics,  physiology
Reg. No./Substance:
0/Mitogens; EC Protein Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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