| Cell senescence: hypertrophic arrest beyond the restriction point. | |
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MedLine Citation:
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PMID: 17001692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Withdrawal of mitogens (growth factors) arrests normal cells in G0 (quiescence). All other stresses and factors arrest cell cycle beyond the restriction point in G1 and G2 (non-G0 arrest), in the presence of mitogenic stimulation. Strong mitogenic stimuli by themselves cause non-G0 arrest. Unlike G0, arrest beyond restriction point is characterized by both high levels of cyclins and CDK inhibitors, activated mitogenic pathways with a secondary GF resistance, and continuous mass growth (cell hypertrophy). Prolonged hypertrophic arrest culminates in cell senescence. This review discusses that quiescence and senescence are two opposite, mutually exclusive conditions and that cell senescence can be reversed and prevented. |
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Authors:
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Mikhail V Blagosklonny |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of cellular physiology Volume: 209 ISSN: 0021-9541 ISO Abbreviation: J. Cell. Physiol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-10-02 Completed Date: 2007-02-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 592-7 Citation Subset: IM |
Copyright Information:
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(c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Cancer Center, Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208, USA. mblagosklonny@ordwayreseach.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals CDC2 Protein Kinase / metabolism Cell Aging / physiology* Cell Cycle / physiology* DNA Damage Humans Hypertrophy* Life Expectancy Mitogens / metabolism Saccharomyces cerevisiae / genetics, physiology |
| Chemical | |
Reg. No./Substance:
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0/Mitogens; EC 2.7.11.22/CDC2 Protein Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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