Document Detail

Cell research with physically modified microfluidic channels: a review.
MedLine Citation:
PMID:  18584072     Owner:  NLM     Status:  MEDLINE    
An overview of the use of physically modified microfluidic channels towards cell research is presented. The physical modification can be realized either by combining embedded physical micro/nanostructures or a topographically patterned substrate at the micro- or nanoscale inside a channel. After a brief description of the background and the importance of the physically modified microfluidic system, various fabrication methods are described based on the materials and geometries of physical structures and channels. Of many operational principles for microfluidics (electrical, magnetic, optical, mechanical, and so on), this review primarily focuses on mechanical operation principles aided by structural modification of the channels. The mechanical forces are classified into (i) hydrodynamic, (ii) gravitational, (iii) capillary, (iv) wetting, and (v) adhesion forces. Throughout this review, we will specify examples where necessary and provide trends and future directions in the field.
Sun Min Kim; Sung Hoon Lee; Kahp Yang Suh
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-15
Journal Detail:
Title:  Lab on a chip     Volume:  8     ISSN:  1473-0197     ISO Abbreviation:  Lab Chip     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-27     Completed Date:  2008-09-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  1015-23     Citation Subset:  IM    
Department of Mechanical Engineering, Inha University, 253 Young Hyun-dong, Nam-gu, Incheon 402-751, Republic of Korea.
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MeSH Terms
Cells / cytology*
Microfluidic Analytical Techniques / instrumentation*
Research / instrumentation*
Water / chemistry
Reg. No./Substance:

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