| β-cell regeneration: the pancreatic intrinsic faculty. | |
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MedLine Citation:
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PMID: 21067943 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Type I diabetes (T1D) patients rely on cumbersome chronic injections of insulin, making the development of alternate durable treatments a priority. The ability of the pancreas to generate new β-cells has been described in experimental diabetes models and, importantly, in infants with T1D. Here we discuss recent advances in identifying the origin of new β-cells after pancreatic injury, with and without inflammation, revealing a surprising degree of cell plasticity in the mature pancreas. In particular, the inducible selective near-total destruction of β-cells in healthy adult mice uncovers the intrinsic capacity of differentiated pancreatic cells to spontaneously reprogram to produce insulin. This opens new therapeutic possibilities because it implies that β-cells can differentiate endogenously, in depleted adults, from heterologous origins. |
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Authors:
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Renaud Desgraz; Claire Bonal; Pedro L Herrera |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-11-08 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 22 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 34-43 Citation Subset: IM |
Affiliation:
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Department of Cell Physiology and Metabolism, University of Geneva Faculty of Medicine, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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