Document Detail

Cell proliferation patterns in canine infundibular keratinizing acanthoma and well differentiated squamous cell carcinoma of the skin.
MedLine Citation:
PMID:  12152794     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate if the evaluation of cell proliferation of the well differentiated squamous cell carcinoma (WDSCC) and infundibular keratinizing acanthoma (IKA) could be useful in the differential diagnosis between these two tumours. Eighteen IKAs and ten WDSCCs were selected for this study. Two different methods were used to assess the activity of cell proliferation: MIB1 immunohistochemical detection and AgNOR proteins silver staining. The quantification of proliferative parameters was performed by means of an image analyzer and expressed as MIB1 index and AgNOR area (MNORA). Both MIBI immunohistochemical and AgNOR histochemical patterns were different in WDSCC and IKA; moreover analysis of variance showed a significant difference for both parameters employed (MIB1 index, MNORA) between WDSCC and IKA (P<0.003 for MIB1 index; P<0.0001 for AgNOR area). The results show that canine WDSCC and IKA have a different proliferative behaviour and the assessment of cell proliferation can be considered as a useful adjunctive tool to the histopathological investigation in the differential diagnosis of these tumours.
L Della Salda; R Preziosi; M Mazzoni; P S Marcato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of histochemistry : EJH     Volume:  46     ISSN:  1121-760X     ISO Abbreviation:  Eur J Histochem     Publication Date:  2002  
Date Detail:
Created Date:  2002-08-02     Completed Date:  2003-01-16     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  9207930     Medline TA:  Eur J Histochem     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Department of Functions, Structures, Animal Pathology and Biotechnology, University of Teramo, Italy.
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MeSH Terms
Carcinoma, Squamous Cell / metabolism,  pathology,  veterinary*
Cell Division
Diagnosis, Differential
Immunoenzyme Techniques / veterinary
Keratoacanthoma / metabolism,  pathology,  veterinary*
Ki-67 Antigen / metabolism
Nucleolus Organizer Region
Silver Staining / veterinary
Skin Neoplasms / metabolism,  pathology,  veterinary*
Reg. No./Substance:
0/Ki-67 Antigen

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