Document Detail

Cell proliferation and p27Kip1 expression in endophytic schneiderian papillomas.
MedLine Citation:
PMID:  12150617     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To clarify epithelial cell proliferation and p27Kip1 expression along the stepwise histological changes from endophytic schneiderian papillomas to associated carcinomas. STUDY DESIGN: Retrospective investigation involved surgical specimens from 58 patients. METHODS: Immunohistochemical assessment involved the nuclear Ki67 antigen expressed in proliferating cells. Further, the cyclin-dependent kinase (cdk) inhibitor p27Kip1 was assessed. Binding of p27Kip1 to the cyclin E-cdk2 complex inhibits this kinase, which results in cell cycle arrest. The expression rates of both proteins were compared between nonpapillomatous nasal mucosa, endophytic schneiderian papillomas, carcinoma in situ, and invasive squamous cell carcinomas. Statistics involved the Wilcoxon and Mann-Whitney u tests. Significance was set at P <.05. RESULTS: Comparable cell proliferation rates were observed between non-papillomatous nasal mucosa and cylindrical cell papillomas. Significant increases in cell proliferation were found along the stepwise series of histological changes involving non-papillomatous nasal mucosa, columnar epithelium in inverted papillomas, transitional and squamous metaplasia in inverted papillomas, and dysplastic inverted papillomas (P <.05, respectively). A tendency toward increased cell proliferation in carcinoma in situ compared with dysplastic inverted papillomas was present; however, this was not statistically significant. The expression rates of p27Kip1 were comparable between non-papillomatous nasal mucosa and all histological subtypes within nondysplastic endophytic schneiderian papillomas. Significantly reduced p27Kip1 expression was found in surface cells in dysplastic compared with non-dysplastic inverted papillomas, as well as in the total number of cells in carcinoma in situ compared with dysplastic inverted papillomas (P <.05, respectively). CONCLUSIONS: Inverted papillomas but not cylindrical cell papillomas show increased cell proliferation compared with nonpapillomatous nasal mucosa. Stepwise increases in cell proliferation accompany the consecutive histological changes within inverted papillomas. Among them, increased cell proliferation along with the development of dysplasia and carcinoma in situ is associated with reduced p27Kip1 expression.
Michael J Schwerer; Adrian Sailer; Klaus Kraft; Heinz Maier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  112     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-08-01     Completed Date:  2002-08-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  852-7     Citation Subset:  IM    
Department of Pathology, Military Hospital Ulm, Ulm/Donau, Germany.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology
Cell Cycle Proteins / analysis*
Cell Division / physiology*
Cell Transformation, Neoplastic / pathology
Cyclin-Dependent Kinase Inhibitor p27
Enzyme Inhibitors / analysis*
Middle Aged
Nasal Mucosa / pathology
Neoplasm Invasiveness
Nose Neoplasms / pathology*
Papilloma / pathology*
Tumor Suppressor Proteins / analysis*
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Enzyme Inhibitors; 0/Tumor Suppressor Proteins; 147604-94-2/Cyclin-Dependent Kinase Inhibitor p27

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