| Cell proliferation and oxygen diffusion in a vascularising scaffold. | |
| | |
MedLine Citation:
|
PMID: 17554583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The supply of oxygen to proliferating cells within a scaffold is a key factor for the successful building of new tissue in soft tissue engineering applications. A recent in vivo model, where an arteriovenous loop is placed in a scaffold, allows a vascularising network to form within a scaffold, establishing an oxygen source within, rather than external, to the scaffold. A one-dimensional model of oxygen concentration, cell proliferation and cell migration inside such a vascularising scaffold is developed and investigated. In addition, a vascularisation model is presented, which supports a vascularisation front which moves at a constant speed. The effects of vascular growth, homogenous and heterogenous seeding, diffusion of cells and critical hypoxic oxygen concentration are considered. For homogenous seeding, a relationship between the speed of the vascular front and a parameter defining the rate of oxygen diffusion relative to the rate of oxygen consumption determines whether a hypoxic region exists at some time. In particular, an estimate of the length of time that a fixed point in the scaffold will remain under hypoxic conditions is determined. For heterogenous seeding, a Fisher-like travelling wave of cells is established behind the vascular front. These findings provide a fundamental understanding of the important interplay between the parameters and allows for a theoretical assessment of a seeding strategy in a vascularising scaffold. |
| | |
Authors:
|
Kerry A Landman; Anna Q Cai |
Related Documents
:
|
3236003 - Resonance raman spectroscopy of hemoglobin in intact cells: a probe of oxygen uptake by... 10708333 - Mechanisms of parenchymal cell death in-vivo after microvascular hemorrhage. 17922813 - Sweet delivery - sugar translocators as ports of entry for antisense oligodeoxynucleoti... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-06-07 |
Journal Detail:
|
Title: Bulletin of mathematical biology Volume: 69 ISSN: 0092-8240 ISO Abbreviation: Bull. Math. Biol. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-09-17 Completed Date: 2008-01-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401404 Medline TA: Bull Math Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 2405-28 Citation Subset: IM |
Affiliation:
|
Department of Mathematics and Statistics, University of Melbourne, Victoria, 3010, Australia. k.landman@ms.unimelb.edu.au |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Angiogenesis Inducing Agents / metabolism Animals Anoxia Cell Count Cell Hypoxia Cell Movement / physiology Cell Proliferation* Diffusion Humans Models, Biological* Neovascularization, Physiologic / physiology* Oxygen / chemistry, metabolism* Tissue Culture Techniques / methods Tissue Engineering / methods Tissue Scaffolds* |
| Grant Support | |
ID/Acronym/Agency:
|
DP0557990/DP/NCCDPHP CDC HHS |
| Chemical | |
Reg. No./Substance:
|
0/Angiogenesis Inducing Agents; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Voice recognition dictation: radiologist as transcriptionist.
Next Document: Kinetics of aggregate formation in social insects.