Document Detail

Cell proliferation inhibition in remitting multiple sclerosis CSF.
MedLine Citation:
PMID:  16772713     Owner:  NLM     Status:  MEDLINE    
Sixty percent of the CSF samples from 21 multiple sclerosis (MS) patients in remission inhibited cellular proliferation of a variety of neuronal and glial cell lines. No inhibition was observed with CSF from relapsing or progressive MS patients (0/19). Two of 82 samples from stationary MS patients were positive. No inhibition was found in MS sera. The CSF samples had no effect on myelination of mouse organotypic cerebellar cultures. Like MS cellular proliferation and subsequent lesion formation, the 'deactivation' of the lesion also is an active defined process, rather than just the cessation of the immunological events. Furthermore, approximately 20% of samples from Huntington's, Alzheimer's and Parkinson's disease patients were also positive. However, no inhibition was seen in CSF from amyotrophic lateral sclerosis patients or controls.
Fred C Westall; Fredrick J Seil
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-06-13
Journal Detail:
Title:  European neurology     Volume:  55     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-04     Completed Date:  2006-09-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  214-21     Citation Subset:  IM    
Institute for Disease Research, Temecula, Calif. 92589, USA.
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MeSH Terms
Cell Division
Cell Line
Cerebellum / pathology
Cerebrospinal Fluid
Longitudinal Studies
Middle Aged
Motor Neuron Disease / cerebrospinal fluid
Multiple Sclerosis / classification,  pathology
Multiple Sclerosis, Relapsing-Remitting / cerebrospinal fluid*,  classification,  pathology*
Myelin Sheath / pathology*
Grant Support

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