| Cell proliferation in the small intestine and colon of intravenously fed rats: effects of urogastrone-epidermal growth factor. | |
| | |
MedLine Citation:
|
PMID: 1391227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is marked intestinal hypoplasia in the intestine of intravenously fed (TPN) rats. Recombinant urogastrone-epidermal growth factor (URO-EGF) reversed these changes by significantly increasing the length of the intestinal crypts. Crypt diameter, however, was not affected to the same extent. Few differences in labelling indices were seen between the orally fed and TPN groups, however, this was the consequence of the concomitant changes in crypt population. The number of mitoses and labelled cells per crypt, and thus the crypt cell production rates, were significantly decreased in the TPN group when compared to the orally fed. URO-EGF significantly increased both proliferative indices and the number of dividing cells per crypt. Crypt cell production in the small intestine was restored to those levels seen in the orally fed rats, moreover, labelling per crypt in the colon was increased to more than twice that of orally fed rats. The location of the mean labelling position and the half maximum labelling position followed the changes in crypt length in the small intestine, but to a lesser extent; thus the growth fraction was significantly increased in the TPN rats in comparison with the orally fed and the URO-EGF treated groups. Similar changes in these positions were seen in the colon, but the growth fraction was much reduced in the URO-EGF treated rats, as a consequence of the large increase in crypt length without a concomitant alteration in label distribution. |
| | |
Authors:
|
R A Goodlad; C Y Lee; N A Wright |
Related Documents
:
|
1410767 - Morphofunctional changes in gastrointestinal tract of rats due to cafeteria diet. 16031037 - Giardiasis in intensively reared saanen kids. 3131727 - Effects of chronic protein-calorie malnutrition on small intestinal repair after an acu... 11911117 - Locally and systemically active glucocorticosteroids modify intestinal absorption of li... 3116497 - Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome: low creatine excretion and... 19946757 - Metabolism and tissue distribution of trace elements in broiler chickens' fed diets con... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Cell proliferation Volume: 25 ISSN: 0960-7722 ISO Abbreviation: Cell Prolif. Publication Date: 1992 Sep |
Date Detail:
|
Created Date: 1992-11-17 Completed Date: 1992-11-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9105195 Medline TA: Cell Prolif Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 393-404 Citation Subset: IM |
Affiliation:
|
Imperial Cancer Research Fund, Histopathology Unit, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Cell Count / drug effects Cell Division / drug effects Colon / cytology*, drug effects, physiology Epidermal Growth Factor / administration & dosage, pharmacology* Intestinal Mucosa / cytology, drug effects Intestine, Small / cytology*, drug effects, physiology Male Mitotic Index / drug effects Parenteral Nutrition, Total* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
62229-50-9/Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thyroid hormone conjugates with rhodamine B as fluorescent ligands of human plasma transport protein...
Next Document: Altered proliferative kinetics in PHA-activated human T-lymphocytes treated with the anti-HLA class ...