| Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications. | |
| | |
MedLine Citation:
|
PMID: 10885405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The kinetic features of skin tumors with ductal differentiation (TDD) remain mainly unknown. We selected 88 skin TDD (D-PAS-positive cuticles) classified according to Murphy and Elder's criteria. Tumors studied included 13 poromas, 12 nodular hidradenomas, 10 cylindromas, 6 spiradenomas, 9 syringomas, 9 chondroid syringomas, 7 porocarcinomas, 15 malignant nodular hidradenomas, and 7 not otherwise specified carcinomas. The same tumor areas were evaluated for mitotic figure counting (MFC) and proliferation rate (PR = MIB-1 index), screening 10 consecutive high-power fields (HPFs) in the most cellular areas. Results were recorded by HPF and tumor cellularity, considering both average and standard deviation. Differences were analyzed by Student's t-test and analysis of variance (ANOVA) and considered significant if p<0.05. PR was significantly higher in malignant (23.29 +/- 12.49) than in benign tumors (3.86 +/- 4.44) and in poromanodular hidradenoma (4.99 +/- 3.34) than in spiradenoma-cylindroma-syringoma (1.91 +/- 1.67), but not by malignant tumor type. MFC was significantly higher in malignant (25.52 +/- 4.10) than in benign tumors (1.57 +/- 0.38), showing porocarcinomas the biggest MFC/10 HPF and malignant nodular hidradenomas the highest MFC/1000 cells. PR and MFC are useful malignancy criteria in skin TDD and should be evaluated by tumor cellularity to avoid potential misinterpretations related with tumor heterogeneity. |
| | |
Authors:
|
L Pozo; F Camacho; J J Rios-Martin; S J Diaz-Cano |
Related Documents
:
|
1528955 - Multistage carcinogenesis in mouse skin. 2702725 - A metabolite of butylated hydroxytoluene with potent tumor-promoting activity in mouse ... 18210915 - Practical cryotherapy for skin disease. 6409425 - Stimulation of lymphokine production by teleocidin, aplysiatoxin, and debromoaplysiatoxin. 1940805 - Distribution of vascular permeability factor (vascular endothelial growth factor) in tu... 2724715 - Carcinoma at the esophago-gastric junction--its biological behaviour toward the squamou... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cutaneous pathology Volume: 27 ISSN: 0303-6987 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2000 Jul |
Date Detail:
|
Created Date: 2000-10-18 Completed Date: 2000-10-25 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 292-7 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, The Royal London Hospital, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acrospiroma
/
chemistry,
pathology* Adenoma, Sweat Gland / chemistry, pathology* Adolescent Adult Aged Aged, 80 and over Antibodies, Monoclonal Antigens, Nuclear Cell Division Female Humans Ki-67 Antigen / analysis Male Middle Aged Mitotic Index Nuclear Proteins / analysis Sweat Gland Neoplasms / chemistry, pathology* Syringoma / chemistry, pathology* |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Antigens, Nuclear; 0/Ki-67 Antigen; 0/Nuclear Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: bcl-2 protein expression in aggressive and non-aggressive basal cell carcinomas.
Next Document: Squamous metaplasia of sebaceous gland.