Document Detail

Cell proliferation in the mouse parotid gland after unilateral parotidectomy.
MedLine Citation:
PMID:  455486     Owner:  NLM     Status:  MEDLINE    
Unilateral parotidectomy with or without total submandibulectomy has been used to induce cell proliferation in mouse parotid gland. Maximum DNA synthesis and mitosis were recorded four and five days after the operation. The double operation increased the proliferative response. Such proliferative stimulii was not accompanied by secretion and was sex independent. On the other hand, the response decreased with age. RNA and protein synthesis inhibitors showed that the stimulation of DNA synthesis depends on early protein synthesis, which seems to be synthesized on a preexisting template.
J Sans; N Galanti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biology international reports     Volume:  3     ISSN:  0309-1651     ISO Abbreviation:  Cell Biol. Int. Rep.     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7708050     Medline TA:  Cell Biol Int Rep     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  25-34     Citation Subset:  IM    
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MeSH Terms
Cell Division
Cycloheximide / pharmacology
DNA / biosynthesis
Dactinomycin / pharmacology
Parotid Gland / cytology*,  metabolism,  surgery
Submandibular Gland / surgery
Reg. No./Substance:
50-76-0/Dactinomycin; 66-81-9/Cycloheximide; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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