Document Detail


Cell proliferation in the Rana catesbeiana auditory medulla over metamorphic development.
MedLine Citation:
PMID:  16288474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During metamorphic development, bullfrogs (Rana catesbeiana) undergo substantial morphological, anatomical, and physiological changes as the animals prepare for the transition from a fully-aquatic to a semi-terrestrial existence. Using BrdU incorporation and immunohistochemistry, we quantify changes in cell proliferation in two key auditory brainstem nuclei, the dorsolateral nucleus and the superior olivary nucleus, over the course of larval and early postmetamorphic development. From hatchling through early larval stages, numbers of proliferating cells increase in both nuclei, paralleling the overall increase in total numbers of cells available for labeling. Numbers of proliferating cells in the superior olivary nucleus decrease during the late larval and deaf periods, and significantly increase during metamorphic climax. Proliferating cells in the dorsolateral nucleus increase in number from hatchling to late larval stages, decrease during the deaf period, and increase during climax. In both nuclei, numbers of proliferating cells decrease during the postmetamorphic froglet stage, despite increases in the number of cells available for label. Newly generated cells express either glial- or neural-specific phenotypes beginning between 1 week and 1 month post-BrdU injection, respectively, while some new cells express gamma-aminobutyric acid within 2 days of mitosis. Our data show that these auditory nuclei dramatically up-regulate mitosis immediately prior to establishment of a transduction system based on atmospheric hearing.
Authors:
Judith A Chapman; Joshua L Weinstein; Andrea Megela Simmons
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of neurobiology     Volume:  66     ISSN:  0022-3034     ISO Abbreviation:  J. Neurobiol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2005-12-28     Completed Date:  2006-04-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213640     Medline TA:  J Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-33     Citation Subset:  IM    
Affiliation:
Department of Psychology, Brown University, Providence, Rhode Island 02912-1853, USA. Judith_Chapman@brown.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Pathways / cytology,  growth & development*
Cell Proliferation*
Image Processing, Computer-Assisted
Immunohistochemistry
Medulla Oblongata / cytology,  growth & development*
Metamorphosis, Biological / physiology*
Rana catesbeiana / growth & development*
Grant Support
ID/Acronym/Agency:
F31 DC6776/DC/NIDCD NIH HHS; R01 DC05257/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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