| Cell proliferation and histologic classification of bronchogenic carcinoma. | |
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MedLine Citation:
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PMID: 198555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rate of cell proliferation of 99 bronchogenic carcinomas (94 primary tumors and 5 metastases) was evaluated from the labeling index after in vitro incorporation of [3H]thymidine; the rate was then correlated with the histologic tumor type according to the classification of the World Health Organization (WHO). Cell proliferation was significantly slower in adenocarcinoma (WHO type III) than in squamous cell carcinoma (WHO type I), small cell anaplastic carcinoma (WHO type II), and large cell carcinoma (WHO type IV). Cells proliferated at a significantly higher rate in large cell carcinoma than in the squamous cell type, whereas no significant difference was observed between the other cell types. Dedifferentiated forms of squamous cell carcinomas had a higher rate of cell proliferation than did differentiated forms of the same cell type. Metastases of small cell anaplastic carcinoma did not differ in cell proliferation from primary tumors of the same cell type. |
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Authors:
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B Hainau; P Dombernowsky; H H Hansen; S Borgeskov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 59 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1977-11-25 Completed Date: 1977-11-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1113-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism,
pathology Adult Aged Carcinoma, Bronchogenic / metabolism, pathology* Carcinoma, Small Cell / metabolism, pathology Carcinoma, Squamous Cell / metabolism, pathology Cell Differentiation Cell Division Female Humans Kinetics Lung Neoplasms / metabolism, pathology* Male Middle Aged Neoplasm Metastasis / pathology Thymidine / metabolism |
| Chemical | |
Reg. No./Substance:
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50-89-5/Thymidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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