Document Detail

Cell proliferation and histologic classification of bronchogenic carcinoma.
MedLine Citation:
PMID:  198555     Owner:  NLM     Status:  MEDLINE    
The rate of cell proliferation of 99 bronchogenic carcinomas (94 primary tumors and 5 metastases) was evaluated from the labeling index after in vitro incorporation of [3H]thymidine; the rate was then correlated with the histologic tumor type according to the classification of the World Health Organization (WHO). Cell proliferation was significantly slower in adenocarcinoma (WHO type III) than in squamous cell carcinoma (WHO type I), small cell anaplastic carcinoma (WHO type II), and large cell carcinoma (WHO type IV). Cells proliferated at a significantly higher rate in large cell carcinoma than in the squamous cell type, whereas no significant difference was observed between the other cell types. Dedifferentiated forms of squamous cell carcinomas had a higher rate of cell proliferation than did differentiated forms of the same cell type. Metastases of small cell anaplastic carcinoma did not differ in cell proliferation from primary tumors of the same cell type.
B Hainau; P Dombernowsky; H H Hansen; S Borgeskov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  59     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1977-11-25     Completed Date:  1977-11-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1113-8     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / metabolism,  pathology
Carcinoma, Bronchogenic / metabolism,  pathology*
Carcinoma, Small Cell / metabolism,  pathology
Carcinoma, Squamous Cell / metabolism,  pathology
Cell Differentiation
Cell Division
Lung Neoplasms / metabolism,  pathology*
Middle Aged
Neoplasm Metastasis / pathology
Thymidine / metabolism
Reg. No./Substance:

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