Document Detail

Cell proliferation as a prognostic indicator in conjunctival malignant melanoma.
MedLine Citation:
PMID:  8101047     Owner:  NLM     Status:  MEDLINE    
Expression of proliferating cell nuclear antigen, a DNA polymerase delta auxiliary protein, was studied in 20 specimens from 20 patients with conjunctival malignant melanoma by means of the total number of cells that showed immunoreactivity per square millimeter. The countings were shown to be reproducible with minimal intraobserver variability. In a multifactor analysis of variance (ANOVA) that adjusted for possible confounders, patients who subsequently died of metastatic disease had significantly higher counts of cells that were positive for proliferating cell nuclear antigen per square millimeter (P = .0011) than patients with a minimum survival of five years without clinical signs of metastatic disease. A multivariate Cox regression model confirmed the independent prognostic value (P = .048) of the cell counts. Individual hazard ratios were estimated in a final Cox model and two groups of patients with low and high hazard ratios were formed. Five-year cumulated survival proportions of the two groups were 90% and 60%, respectively. The total count of cells displaying immunoreactivity for proliferating cell nuclear antigen per square millimeter may be used as a prognostic indicator in patients with conjunctival melanoma.
S Seregard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  116     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-08-12     Completed Date:  1993-08-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  AIM; IM    
Division of Ophthalmic Pathology and Oncology, St. Erik's Eye Hospital, Stockholm, Sweden.
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MeSH Terms
Analysis of Variance
Antigens, Neoplasm / analysis
Autoantigens / analysis
Cell Count
Cell Division
Conjunctival Neoplasms / metabolism,  pathology*
Immunoenzyme Techniques
Melanoma / metabolism,  pathology*
Nuclear Proteins / analysis
Observer Variation
Proliferating Cell Nuclear Antigen
Proportional Hazards Models
Reproducibility of Results
Tumor Markers, Biological
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Autoantigens; 0/Nuclear Proteins; 0/Proliferating Cell Nuclear Antigen; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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