Document Detail

Cell populations in the endocrine pancreas of human neonates and infants.
MedLine Citation:
PMID:  6116638     Owner:  NLM     Status:  MEDLINE    
Pancreases from normoglycaemic neonates (less than 15 days), infants (6 months) and adults were examined using immunoperoxidase techniques. Sections taken from five regions of the gland were analysed by morphometry. The volume density of total endocrine tissue was found to be higher than previously reported: 15% in neonates, 6-7% in infants and 2-3% in adults. In neonates, many endocrine cells were located in small clusters, sometimes budding from ducts, and up to 15% were isolated in ducts and acini. Similar clusters were still present, though less frequent, in infants. The relative proportion of all cell types varied only slightly between the different regions, except in the posterior part of the head, which comprised 90% of all PP(polypeptide) cells. With age, the proportion of somatostatin cells decreased (from about 30% in neonates to about 10% in adults), that of insulin cells increased (50 to 70%) and that of glucagon cells remained stable (20%). In the posterior part of the head, the proportion of PP cells tended to be higher in adults than in neonates or infants. This study shows that both the endocrine cell populations and the proportion of endocrine tissue in the pancreas change markedly in early life. It also suggests that "nesidioblastosis" is a normal feature of the pancreas of normoglycaemic neonates and young infants.
J Rahier; J Wallon; J C Henquin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetologia     Volume:  20     ISSN:  0012-186X     ISO Abbreviation:  Diabetologia     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-12-16     Completed Date:  1981-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  540-6     Citation Subset:  IM    
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MeSH Terms
Cell Count
Glucagon / biosynthesis
Immunoenzyme Techniques
Infant, Newborn
Insulin / biosynthesis
Islets of Langerhans / cytology*
Middle Aged
Somatostatin / biosynthesis
Reg. No./Substance:
11061-68-0/Insulin; 51110-01-1/Somatostatin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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