Document Detail

Cell polarity: models and mechanisms from yeast, worms and flies.
MedLine Citation:
PMID:  23222437     Owner:  NLM     Status:  In-Data-Review    
Determinants of cell polarity orient the behaviour of many cell types during development. Pioneering genetic screens in yeast, worms and flies have identified key polarity determinants that are evolutionarily conserved across the animal kingdom. Recent work in these three model organisms has combined computer modelling with experimental analysis to reveal the molecular mechanisms that drive the polarisation of determinants. Two key principles have emerged: the first is the requirement for a positive-feedback loop to drive self-recruitment of determinants to the plasma membrane; the second is the requirement for mutual antagonism between determinants that localise to opposite ends of the cell.
Barry J Thompson
Related Documents :
24576537 - Cyp26b1 promotes male germ cell differentiation by suppressing stra8-dependent meiotic ...
24868467 - Evaluating cytotoxicity of hyaluronate targeted solid lipid nanoparticles of etoposide ...
23563487 - Brain morphophysiology of africanized bee apis mellifera exposed to sublethal doses of ...
24010837 - Desialylation of surface receptors as a new dimension in cell signaling.
22161117 - Genotoxic effect of ciprofloxacin during photolytic decomposition monitored by the in v...
18160257 - Wnt6 induces the specification and epithelialization of f9 embryonal carcinoma cells to...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  140     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  IM    
Cancer Research UK, London Research Institute, Lincoln's Inn Fields, London WC2A 3LY, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Endoreplication and polyploidy: insights into development and disease.
Next Document:  Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properti...