Document Detail


Cell polarity: models and mechanisms from yeast, worms and flies.
MedLine Citation:
PMID:  23222437     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Determinants of cell polarity orient the behaviour of many cell types during development. Pioneering genetic screens in yeast, worms and flies have identified key polarity determinants that are evolutionarily conserved across the animal kingdom. Recent work in these three model organisms has combined computer modelling with experimental analysis to reveal the molecular mechanisms that drive the polarisation of determinants. Two key principles have emerged: the first is the requirement for a positive-feedback loop to drive self-recruitment of determinants to the plasma membrane; the second is the requirement for mutual antagonism between determinants that localise to opposite ends of the cell.
Authors:
Barry J Thompson
Related Documents :
22718427 - Beware of the commercialization of human cells and tissues: situation in the european u...
23421747 - Using a continuum model to predict closure time of gaps in intestinal epithelial cell l...
23174537 - Involvement of akt isoforms in chemoresistance of endometrial carcinoma cells.
24702307 - Zinc finger dhhc-type containing 13 regulates fate specification of ectoderm and mesode...
1322657 - Replicative difference in early-passage feline brain cells among feline immunodeficienc...
16187487 - Changes in sertoli cells of albino rats induced by azadirachta indica a. juss leaves.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  140     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  IM    
Affiliation:
Cancer Research UK, London Research Institute, Lincoln's Inn Fields, London WC2A 3LY, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Endoreplication and polyploidy: insights into development and disease.
Next Document:  Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properti...