| Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis. | |
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MedLine Citation:
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PMID: 7251666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Locomoting polymorphonuclear leukocytes (PMNs) exhibit a morphological polarity. We demonstrate that they also exhibit a behavioral polarity in their responsiveness to chemotactic factor stimulation. This is demonstrated by (a) the pattern of their locomotion in a homogeneous concentration of chemotactic factors, (b) their responses to increases in the homogeneous concentration of chemotactic factors, and (c) their responses to changes in the direction of a chemotactic gradient. The behavioral polarity is not a function of the rate of locomotion of the particular stimulant used to orient the cells, but may reflect an asymmetric distribution of chemotactic receptors or the motile machinery. The polar behavior affects the chemotactic ability of PMNs. The data are discussed in relation to possible mechanisms of sensing a chemotactic gradient. |
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Authors:
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S H Zigmond; H I Levitsky; B J Kreel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of cell biology Volume: 89 ISSN: 0021-9525 ISO Abbreviation: J. Cell Biol. Publication Date: 1981 Jun |
Date Detail:
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Created Date: 1981-09-25 Completed Date: 1981-09-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0375356 Medline TA: J Cell Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 585-92 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Chemotactic Factors
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pharmacology Chemotaxis, Leukocyte* Humans Kinetics Neutrophils / cytology, physiology* Oligopeptides / pharmacology Pseudopodia / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL 15835/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemotactic Factors; 0/Oligopeptides; 71901-21-8/F-chemotactic peptide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Cell Biol ISSN: 0021-9525 ISSN: 1540-8140 Publisher: The Rockefeller University Press |
Article Information Download PDF  Print publication date: Day: 1 Month: 6 Year: 1981 Volume: 89 Issue: 3 First Page: 585 Last Page: 592 ID: 2111809 Publisher Id: 81239766 PubMed Id: 7251666 |
| Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxis | |
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