| Cell-penetrating peptides, electroporation and drug delivery. | |
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MedLine Citation:
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PMID: 21073236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Certain short polycations, such as trans-activating transcriptional activator and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis. These cell-penetrating peptides can carry with them cargos of 30 amino acids, more than the nominal limit of 500 Da and enough to be therapeutic. An analysis of the electrostatics of a charge outside the cell membrane and some recent experiments suggest that transduction may proceed by molecular electroporation. Ways to target diseased cells, rather than all cells, are discussed. |
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Authors:
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K Cahill |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: IET systems biology Volume: 4 ISSN: 1751-8849 ISO Abbreviation: IET Syst Biol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101301198 Medline TA: IET Syst Biol Country: England |
Other Details:
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Languages: eng Pagination: 367-78 Citation Subset: IM |
Affiliation:
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University of New Mexico, Biophysics Group, Department of Physics & Astronomy, Albuquerque, NM, USA. cahill@unm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / physiology Cell-Penetrating Peptides / administration & dosage*, chemistry, pharmacokinetics Drug Delivery Systems / methods* Drug Stability Electroporation / methods* Humans Lipid Bilayers / chemistry Mammals Membrane Potentials Models, Biological* Neoplasms Static Electricity |
| Chemical | |
Reg. No./Substance:
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0/Cell-Penetrating Peptides; 0/Lipid Bilayers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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