Document Detail

Cell-penetrating peptides, electroporation and drug delivery.
MedLine Citation:
PMID:  21073236     Owner:  NLM     Status:  MEDLINE    
Certain short polycations, such as trans-activating transcriptional activator and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis. These cell-penetrating peptides can carry with them cargos of 30 amino acids, more than the nominal limit of 500 Da and enough to be therapeutic. An analysis of the electrostatics of a charge outside the cell membrane and some recent experiments suggest that transduction may proceed by molecular electroporation. Ways to target diseased cells, rather than all cells, are discussed.
K Cahill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  IET systems biology     Volume:  4     ISSN:  1751-8849     ISO Abbreviation:  IET Syst Biol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101301198     Medline TA:  IET Syst Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  367-78     Citation Subset:  IM    
University of New Mexico, Biophysics Group, Department of Physics & Astronomy, Albuquerque, NM, USA.
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MeSH Terms
Cell Membrane / physiology
Cell-Penetrating Peptides / administration & dosage*,  chemistry,  pharmacokinetics
Drug Delivery Systems / methods*
Drug Stability
Electroporation / methods*
Lipid Bilayers / chemistry
Membrane Potentials
Models, Biological*
Static Electricity
Reg. No./Substance:
0/Cell-Penetrating Peptides; 0/Lipid Bilayers

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