Document Detail


Cell-penetrating peptides for the delivery of nucleic acids.
MedLine Citation:
PMID:  22594635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Different gene therapy approaches have gained extensive interest lately and, after many initial hurdles, several promising approaches have reached to the clinics. Successful implementation of gene therapy is heavily relying on finding efficient measures to deliver genetic material to cells. Recently, non-viral delivery of nucleic acids and their analogs has gained significant interest. Among non-viral vectors, cell-penetrating peptides (CPPs) have been extensively used for the delivery of nucleic acids both in vitro and in vivo.
AREAS COVERED: In this review we will discuss recent advances of CPP-mediated delivery of nucleic acid-based cargo, concentrating on the delivery of plasmid DNA, splice-correcting ONs, and small-interfering RNAs.
EXPERT OPINION: CPPs have proved their potential as carriers for nucleic acids. However, similarly to other non-viral vectors, CPPs require further development, as efficient systemic delivery is still seldom achieved. To achieve this, CPPs should be modified with entities that would allow better endosomal escape, targeting of specific tissues and cells, and shielding agents that increase the half-life of the vehicles. Finally, to understand the clinical potential of CPPs, they require more thorough investigations in clinically relevant disease models and in pre-clinical and clinical studies.
Authors:
Taavi Lehto; Kaido Kurrikoff; Ülo Langel
Related Documents :
8819185 - Excitatory effects of volatile fatty acids on the in vitro motility of the rumen of sheep.
22338615 - Hyaluronic acid in ankle osteoarthritis: why evidence of efficacy is still lacking?
42125 - The inhibitory effect of bovine rumen fluid on salmonella typhimurium.
24056635 - The in vitro effects of retrograded starch (resistant starch type 3) from lotus seed st...
19958435 - The science and art of hyaluronic acid dermal filler use in esthetic applications.
15058385 - Genotype of stearoyl-coa desaturase is associated with fatty acid composition in japane...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-05-17
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  9     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-20     Completed Date:  2013-04-22     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  823-36     Citation Subset:  IM    
Affiliation:
University of Tartu, Institute of Technology, Laboratory of Molecular Biotechnology, Tartu, Estonia. tlehto@ut.ee
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell-Penetrating Peptides*
Drug Carriers*
Genetic Therapy
Genetic Vectors
Humans
Nucleic Acids / administration & dosage*
Oligonucleotides / administration & dosage
Plasmids
RNA, Small Interfering / administration & dosage
Chemical
Reg. No./Substance:
0/Cell-Penetrating Peptides; 0/Drug Carriers; 0/Nucleic Acids; 0/Oligonucleotides; 0/RNA, Small Interfering

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Quantile Uncertainty and Value-at-Risk Model Risk.
Next Document:  Immobilization of laccase on polyacrylamide and polyacrylamide - ? - carragennan-based semi-interpen...