Document Detail

Cell-penetrating peptides for the delivery of nucleic acids.
MedLine Citation:
PMID:  22594635     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Different gene therapy approaches have gained extensive interest lately and, after many initial hurdles, several promising approaches have reached to the clinics. Successful implementation of gene therapy is heavily relying on finding efficient measures to deliver genetic material to cells. Recently, non-viral delivery of nucleic acids and their analogs has gained significant interest. Among non-viral vectors, cell-penetrating peptides (CPPs) have been extensively used for the delivery of nucleic acids both in vitro and in vivo.
AREAS COVERED: In this review we will discuss recent advances of CPP-mediated delivery of nucleic acid-based cargo, concentrating on the delivery of plasmid DNA, splice-correcting ONs, and small-interfering RNAs.
EXPERT OPINION: CPPs have proved their potential as carriers for nucleic acids. However, similarly to other non-viral vectors, CPPs require further development, as efficient systemic delivery is still seldom achieved. To achieve this, CPPs should be modified with entities that would allow better endosomal escape, targeting of specific tissues and cells, and shielding agents that increase the half-life of the vehicles. Finally, to understand the clinical potential of CPPs, they require more thorough investigations in clinically relevant disease models and in pre-clinical and clinical studies.
Taavi Lehto; Kaido Kurrikoff; Ülo Langel
Related Documents :
15237625 - Understanding odorants associated with compost, biomass facilities, and the land applic...
22859225 - Hyaluronic acid fillers on the horizon: roundtable discussion.
20580225 - Evaluation of feeding glycerol on free-fatty acid production and fermentation kinetics ...
8180835 - Recognition of propionic acid vapor after removal of the olfactory bulb area associated...
23647675 - Cutaneous delivery of α-tocopherol and lipoic acid using microemulsions: influence of ...
24078775 - Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleuki...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-05-17
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  9     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-20     Completed Date:  2013-04-22     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  823-36     Citation Subset:  IM    
University of Tartu, Institute of Technology, Laboratory of Molecular Biotechnology, Tartu, Estonia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell-Penetrating Peptides*
Drug Carriers*
Genetic Therapy
Genetic Vectors
Nucleic Acids / administration & dosage*
Oligonucleotides / administration & dosage
RNA, Small Interfering / administration & dosage
Reg. No./Substance:
0/Cell-Penetrating Peptides; 0/Drug Carriers; 0/Nucleic Acids; 0/Oligonucleotides; 0/RNA, Small Interfering

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quantile Uncertainty and Value-at-Risk Model Risk.
Next Document:  Immobilization of laccase on polyacrylamide and polyacrylamide - ? - carragennan-based semi-interpen...