Document Detail

Cell origin and identity in limb regeneration and development.
MedLine Citation:
PMID:  1709617     Owner:  NLM     Status:  MEDLINE    
The occurrence of limb regeneration in adult urodele amphibians raises fundamental questions about the relationship between development and regeneration. The use of monoclonal antibodies as cell markers has provided clear evidence that blastemal cells, the progenitor cells of the regenerate, are not the same as limb bud cells in the embryo. For one of these antibodies the distinction has been traced to the relationship between limb regeneration and the nerve supply. Innervation of the limb bud during development appears to establish nerve-dependent growth control for regeneration. The cell markers have also contributed to the problem of how the blastemal cells arise after amputation, although several important questions remain to be answered.
P Ferretti; J P Brockes
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Glia     Volume:  4     ISSN:  0894-1491     ISO Abbreviation:  Glia     Publication Date:  1991  
Date Detail:
Created Date:  1991-06-25     Completed Date:  1991-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806785     Medline TA:  Glia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  214-24     Citation Subset:  IM    
Ludwig Institute for Cancer Research Middlesex Hospital/University College Branch, London, United Kingdom.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Biological Markers
Cell Differentiation
Cell Movement
DNA / analysis
Extremities / embryology,  innervation,  physiology*
Keratins / analysis
Salamandridae / embryology,  physiology*
Stem Cells / cytology*
Wound Healing / physiology
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Biological Markers; 68238-35-7/Keratins; 9007-49-2/DNA

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