Document Detail


Cell movements controlled by the Notch signalling cascade during foregut development in Drosophila.
MedLine Citation:
PMID:  14998929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Notch signalling is an evolutionarily conserved cell interaction mechanism, the role of which in controlling cell fate choices has been studied extensively. Recent studies in both vertebrates and invertebrates revealed additional functions of Notch in proliferation and apoptotic events. We provide evidence for an essential role of the Notch signalling pathway during morphogenetic cell movements required for the formation of the foregut-associated proventriculus organ in the Drosophila embryo. We demonstrate that the activation of the Notch receptor occurs in two rows of boundary cells in the proventriculus primordium. The boundary cells delimit a population of foregut epithelial cells that invaginate into the endodermal midgut layer during proventriculus morphogenesis. Notch receptor activation requires the expression of its ligand Delta in the invaginating cells and apical Notch receptor localisation in the boundary cells. We further show that the movement of the proventricular cells is dependent on the short stop gene that encodes the Drosophila plectin homolog of vertebrates and is a cytoskeletal linker protein of the spectraplakin superfamily. short stop is transcriptionally activated in response to the Notch signalling pathway in boundary cells and we demonstrate that the localisation of the Notch receptor and Notch signalling activity depend on short stop activity. Our results provide a novel link between the Notch signalling pathway and cytoskeletal reorganisation controlling cell movement during the development of foregut-associated organs.
Authors:
Bernhard Fuss; Frank Josten; Maritta Feix; Michael Hoch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-03-03
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  131     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-16     Completed Date:  2004-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  1587-95     Citation Subset:  IM    
Affiliation:
Universität Bonn, Institut für Molekulare Physiologie und Entwicklungsbiologie, Abteilung für Molekulare Entwicklungsbiologie, Poppelsdorfer Schloss, D-53115 Bonn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Animals
Cell Movement / physiology*
Cytoskeleton / metabolism
Drosophila Proteins / genetics,  metabolism
Drosophila melanogaster / anatomy & histology*,  embryology*
Embryonic Structures / cytology,  metabolism*
Gene Expression Regulation, Developmental
Genes, Reporter
In Situ Hybridization
Membrane Proteins / genetics,  metabolism*
Microfilament Proteins / genetics,  metabolism
Morphogenesis*
Nerve Tissue Proteins / genetics,  metabolism
Receptors, Notch
Signal Transduction / physiology*
Chemical
Reg. No./Substance:
0/Actins; 0/Drosophila Proteins; 0/Membrane Proteins; 0/Microfilament Proteins; 0/Nerve Tissue Proteins; 0/Receptors, Notch; 0/notch protein, Drosophila; 0/shot protein, Drosophila

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