| Cell migration through small gaps. | |
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MedLine Citation:
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PMID: 16871382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell motility is a fundamental process associated with many phenomena in nature, such as immune response, wound healing, and cancer metastasis. In these processes, cells must squeeze through cell layers, and we characterize this ability to actively produce forces and simultaneously adapt their shapes. We have measured forward forces up to 15 nN that a migrating keratocyte was able to generate, in order to adjust its shape and successfully force its way under and past an obstacle. We also observed that 34 nN was capable of stalling the cell's forward motion. Furthermore, we measured that under compression stresses up to 1,165 pN/micro m2 (1,165 Pa), cell morphology, and velocity remained unchanged. Additionally, we found that keratocytes were able to compress themselves up to 80% vertically in order to squeeze through a gap as small as 500 nm. |
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Authors:
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Claudia A Brunner; Allen Ehrlicher; Bernd Kohlstrunk; Detlef Knebel; Josef A Käs; Michael Goegler |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-27 |
Journal Detail:
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Title: European biophysics journal : EBJ Volume: 35 ISSN: 0175-7571 ISO Abbreviation: Eur. Biophys. J. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-29 Completed Date: 2007-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8409413 Medline TA: Eur Biophys J Country: Germany |
Other Details:
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Languages: eng Pagination: 713-9 Citation Subset: IM |
Affiliation:
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Institute for Soft Matter Physics, University of Leipzig, Linnéstrasse 5, 04103, Leipzig, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Movement* Cell Shape Cells, Cultured Epithelial Cells / physiology* Goldfish Polystyrenes Stress, Mechanical |
| Chemical | |
Reg. No./Substance:
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0/Polystyrenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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