Document Detail

Cell-mediated immunosuppressive mechanisms induced by UV radiation.
MedLine Citation:
PMID:  8934749     Owner:  NLM     Status:  MEDLINE    
Soon after UV exposure, mast cells degranulate, possibly because of the release of the mediators and cytokines from the epidermis, and there are subsequent vascular changes and cellular infiltration. Within a few hours, the soluble mediator milieu of UV-exposed skin becomes exceedingly complex and replete with interactions. Leukocytes newly entering the skin, as well as those already in the skin, must respond to these inflammatory signals. Altered antigen presentation and immune suppression likely derive from alterations induced in the APC that comprise the post-UV leukocyte population of the skin. Many of these mechanisms may explain the effectiveness of phototherapy in atopic dermatitis and psoriasis.
K D Cooper
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  63     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-12-31     Completed Date:  1996-12-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  400-6     Citation Subset:  IM    
Department of Dermatology, Case Western Reserve University and University Hospitals of Cleveland, OH, USA.
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MeSH Terms
Antigen Presentation / radiation effects
Dermatitis, Contact / immunology
Immune Tolerance / radiation effects
Immunity, Cellular / radiation effects*
Neoplasms, Radiation-Induced / etiology
Skin / cytology,  immunology,  radiation effects
Skin Neoplasms / etiology
Ultraviolet Rays / adverse effects*

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