Document Detail

Cell mechanics of alveolar epithelial cells (AECs) and macrophages (AMs).
MedLine Citation:
PMID:  18565804     Owner:  NLM     Status:  MEDLINE    
Cell mechanics provides an integrated view of many biological phenomena which are intimately related to cell structure and function. Because breathing constitutes a sustained motion synonymous with life, pulmonary cells are normally designed to support permanent cyclic stretch without breaking, while receiving mechanical cues from their environment. The authors study the mechanical responses of alveolar cells, namely epithelial cells and macrophages, exposed to well-controlled mechanical stress in order to understand pulmonary cell response and function. They discuss the principle, advantages and limits of a cytoskeleton-specific micromanipulation technique, magnetic bead twisting cytometry, potentially applicable in vivo. They also compare the pertinence of various models (e.g., rheological; power law) used to extract cell mechanical properties and discuss cell stress/strain hardening properties and cell dynamic response in relation to the structural tensegrity model. Overall, alveolar cells provide a pertinent model to study the biological processes governing cellular response to controlled stress or strain.
Sophie Féréol; Redouane Fodil; Gabriel Pelle; Bruno Louis; Daniel Isabey
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-05-13
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  163     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2009-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3-16     Citation Subset:  IM    
Inserm, UMR 841, Biomécanique Cellulaire et Respiratoire, Créteil F-94010, France.
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MeSH Terms
Cellular Structures / physiology
Cytoskeleton / metabolism
Epithelial Cells / cytology,  physiology*,  ultrastructure
Macrophages / physiology*,  ultrastructure
Models, Biological
Pulmonary Alveoli / cytology*
Stress, Mechanical*

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