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Cell lineages, growth and repair of the mouse heart.
MedLine Citation:
PMID:  22918812     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The formation of the heart involves diversification of lineages which differentiate into distinct cardiac cell types or contribute to different regions such as the four cardiac chambers. The heart is the first organ to form in the embryo. However, in parallel with the growth of the organism, before or after birth, the heart has to adapt its size to maintain pumping efficiency. The adult heart has only a mild regeneration potential; thus, strategies to repair the heart after injury are based on the mobilisation of resident cardiac stem cells or the transplantation of external sources of stem cells. We discuss current knowledge on these aspects and raise questions for future research.
Authors:
Fabienne Lescroart; Sigolène M Meilhac
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Results and problems in cell differentiation     Volume:  55     ISSN:  0080-1844     ISO Abbreviation:  Results Probl Cell Differ     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173555     Medline TA:  Results Probl Cell Differ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  263-89     Citation Subset:  IM    
Affiliation:
Department of Developmental Biology, Institut Pasteur, Unit of Molecular Genetics of Development, 75015, Paris, France.
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