Document Detail

Cell lineage assignment of cytogenetic findings in acute lymphoblastic leukemia using combined immunomagnetic cell separation and chromosome preparation.
MedLine Citation:
PMID:  14607762     Owner:  NLM     Status:  MEDLINE    
In acute lymphoblastic leukemia (ALL) abnormal karyotypes frequently constitute a minor part of the dividing cells, and the origin of metaphases in normal diploid cases remains obscure. We used a combination of immunomagnetic cell separation and chromosome preparation (ICSCP) to focus on the metaphases of interest and to assign the chromosome findings to CD19+ or CD7+ leukemia cells.
Harald Rieder; Ina Bachmann; Sylke Busch; Stefan Schwartz; Barbara Reckzeh; Dieter Hoelzer
Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Haematologica     Volume:  88     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2004-02-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  1317-20     Citation Subset:  IM    
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MeSH Terms
Antigens, CD19 / analysis*
Antigens, CD7 / analysis*
Antigens, Neoplasm / analysis*
Bone Marrow Cells / immunology,  pathology
Cell Lineage
Chromosome Painting
Immunomagnetic Separation*
Immunophenotyping / methods*
Middle Aged
Neoplastic Stem Cells / immunology,  pathology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics,  immunology,  pathology*
Reg. No./Substance:
0/Antigens, CD19; 0/Antigens, CD7; 0/Antigens, Neoplasm

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