Document Detail


Cell lineage analysis reveals multipotency of some avian neural crest cells.
MedLine Citation:
PMID:  2457813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A major question in developmental biology is how precursor cells give rise to diverse sets of differentiated cell types. In most systems, it remains unclear whether the precursors can form many or all cell types (multipotent or totipotent), or only a single cell type (predetermined). The question of cell lineage is central to the neural crest because it gives rise to numerous and diverse derivatives including peripheral neurons, glial and Schwann cells, pigment cells, and cartilage. Although the sets of derivatives arising from different populations of neural crest cells have been well-documented, relatively little is known about the developmental potentials of individual neural crest cells. We have iontophoretically microinjected the vital dye, lysinated rhodamine dextran (LRD) into individual dorsal neural tube cells to mark unambiguously their descendants. Many of the resulting labelled clones consisted of multiple cell types, as judged by both their location and morphology. Cells as diverse as sensory neurons, presumptive pigment cells, ganglionic supportive cells, adrenomedullary cells and neural tube cells were found within individual clones. Our results indicate that at least some neural crest cells are multipotent before their departure from the neural tube.
Authors:
M Bronner-Fraser; S E Fraser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  335     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-05     Completed Date:  1988-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  161-4     Citation Subset:  IM    
Affiliation:
Department of Developmental and Cell Biology, University of California, Irvine 92717.
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MeSH Terms
Descriptor/Qualifier:
Animals
Birds / embryology*
Chick Embryo
Clone Cells
Coloring Agents
Dextrans
Microinjections
Microscopy, Fluorescence
Neural Crest / cytology*
Rhodamines
Chemical
Reg. No./Substance:
0/Coloring Agents; 0/Rhodamines; 0/rhodamine dextran; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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