| Cell intrinsic TGF-beta 1 regulation of B cells. | |
| | |
MedLine Citation:
|
PMID: 18523280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
TGF-beta family cytokines play multiple roles in immune responses. TGF-beta1-null mice suffer from multi-organ infiltration that leads to their premature death. T cells play a central role in the TGF-beta1 phenotype, as deficiency of TGF-beta1 only in T cells reproduces the lethal phenotype. Although it is known that TGF-beta1 controls B cells isotype switch and homeostasis, the source responsible for this control has not been characterized. Because of the major role that T cells play in regulating B cell responses, we addressed the T cell dependency of the TGF-beta1 control of B cells. The analysis of T cell-deficient, TGF-beta1 knockout mice and the production of chimeras in which B but not T cells lacked TGF-beta1 allowed us to show that B cells are controlled in part by cell autonomous production of TGF-beta1. |
| | |
Authors:
|
Marilyn J Gros; Philippe Naquet; Rodolphe R Guinamard |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 180 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-06-04 Completed Date: 2008-09-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 8153-8 Citation Subset: AIM; IM |
Affiliation:
|
Aix Marseille Université, Faculté des Sciences de Luminy, Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale U631, Marseille, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens, CD3 / genetics Antigens, T-Independent / genetics, physiology B-Lymphocyte Subsets / immunology*, metabolism* Crosses, Genetic Homeostasis / genetics, immunology Immunoglobulin Class Switching / genetics Immunoglobulin Isotypes / biosynthesis, genetics Mice Mice, Knockout Radiation Chimera / genetics, immunology Spleen / cytology, immunology, metabolism T-Lymphocyte Subsets / immunology, metabolism Transforming Growth Factor beta1 / biosynthesis, genetics, physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD3; 0/Antigens, T-Independent; 0/Cd3e protein, mouse; 0/Immunoglobulin Isotypes; 0/Transforming Growth Factor beta1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor.
Next Document: Molecular basis of the dual functions of 2B4 (CD244).