Document Detail


Cell intrinsic TGF-beta 1 regulation of B cells.
MedLine Citation:
PMID:  18523280     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
TGF-beta family cytokines play multiple roles in immune responses. TGF-beta1-null mice suffer from multi-organ infiltration that leads to their premature death. T cells play a central role in the TGF-beta1 phenotype, as deficiency of TGF-beta1 only in T cells reproduces the lethal phenotype. Although it is known that TGF-beta1 controls B cells isotype switch and homeostasis, the source responsible for this control has not been characterized. Because of the major role that T cells play in regulating B cell responses, we addressed the T cell dependency of the TGF-beta1 control of B cells. The analysis of T cell-deficient, TGF-beta1 knockout mice and the production of chimeras in which B but not T cells lacked TGF-beta1 allowed us to show that B cells are controlled in part by cell autonomous production of TGF-beta1.
Authors:
Marilyn J Gros; Philippe Naquet; Rodolphe R Guinamard
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  180     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-04     Completed Date:  2008-09-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8153-8     Citation Subset:  AIM; IM    
Affiliation:
Aix Marseille Université, Faculté des Sciences de Luminy, Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale U631, Marseille, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD3 / genetics
Antigens, T-Independent / genetics,  physiology
B-Lymphocyte Subsets / immunology*,  metabolism*
Crosses, Genetic
Homeostasis / genetics,  immunology
Immunoglobulin Class Switching / genetics
Immunoglobulin Isotypes / biosynthesis,  genetics
Mice
Mice, Knockout
Radiation Chimera / genetics,  immunology
Spleen / cytology,  immunology,  metabolism
T-Lymphocyte Subsets / immunology,  metabolism
Transforming Growth Factor beta1 / biosynthesis,  genetics,  physiology*
Chemical
Reg. No./Substance:
0/Antigens, CD3; 0/Antigens, T-Independent; 0/Cd3e protein, mouse; 0/Immunoglobulin Isotypes; 0/Transforming Growth Factor beta1

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