Document Detail

Cell interactions in the sea urchin embryo studied by fluorescence photoablation.
MedLine Citation:
PMID:  2188366     Owner:  NLM     Status:  MEDLINE    
In many organisms, interactions between cells play a critical role in the specification of cell fates. In the sea urchin embryo, primary mesenchyme cells (PMCs) regulate the developmental program of a subpopulation of secondary mesenchyme cells (SMCs). The timing of this cell interaction was analyzed by means of a fluorescence photoablation technique, which was used to specifically ablate PMCs at various stages of development. In addition, the PMCs were microinjected into PMC-depleted recipient embryos at different developmental stages and their effect on SMC fate was examined. The critical interaction between PMCs and SMCs was brief and took place late in gastrulation. Before that time, SMCs were insensitive to the suppressive signals transmitted by the PMCs.
C A Ettensohn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  248     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-06-26     Completed Date:  1990-06-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1115-8     Citation Subset:  IM    
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.
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MeSH Terms
Cell Communication / physiology*
Cell Survival / radiation effects
Fluorescent Antibody Technique
Fluorescent Dyes / diagnostic use
Mesoderm / cytology*,  radiation effects
Rhodamines / diagnostic use
Sea Urchins / embryology
Grant Support
Reg. No./Substance:
0/Fluorescent Dyes; 0/Rhodamines; 36877-69-7/rhodamine isothiocyanate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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