Document Detail

Cell individuality: the bistability of competence development.
MedLine Citation:
PMID:  16112577     Owner:  NLM     Status:  MEDLINE    
Heterogeneous development of competence among cells of the bacterium Bacillus subtilis provides an appealing model of cell individuality, an area that is currently attracting considerable research interest. Under appropriate conditions, only a fraction of cells in an isogenic culture become competent for transformation. Two experimental studies have now pinpointed the same auto-stimulatory feedback loop of gene expression as the principal requirement for the establishment of this 'bistable' response.
Simon V Avery
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Trends in microbiology     Volume:  13     ISSN:  0966-842X     ISO Abbreviation:  Trends Microbiol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-19     Completed Date:  2005-12-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9310916     Medline TA:  Trends Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-62     Citation Subset:  IM    
School of Biology, Institute of Genetics, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
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MeSH Terms
Bacillus subtilis / genetics*,  physiology
Gene Expression Regulation, Bacterial*
Transformation, Bacterial*
Grant Support

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