| Cell inactivation by ionizing particles and the shapes of survival curves. | |
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MedLine Citation:
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PMID: 11343427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent experiments concerning the survival of monolayer cells irradiated by different parts of ion Bragg peaks opened a way to a deeper mechanistic understanding of cell inactivation. A new theoretical formula for survival curves has been derived reflecting two basic phases of the given mechanism, i.e. energy transfer to a cell nucleus and subsequent biological effect (depending on the amount of imparted energy). The survival ratio for a given dose has been expressed as a function of inactivation probabilities of individual cells after different numbers of nucleus hits (a given amount of energy being transferred to a cell nucleus in each ion traversal). Having used the experimental data for V79 cells irradiated by protons, deuterons and helium ions in different parts of Bragg peaks preliminary values of these inactivation probabilities for individual cells at different LET values have been established. |
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Authors:
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L Judas; M Lokajícek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of theoretical biology Volume: 210 ISSN: 0022-5193 ISO Abbreviation: J. Theor. Biol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-31 Completed Date: 2001-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: England |
Other Details:
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Languages: eng Pagination: 15-21 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Academic Press. |
Affiliation:
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Institute of Physics, Academy of Sciences, Praha 8, CZ-18040, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Nucleus / radiation effects Cell Survival Cells / radiation effects* Deuterium Dose-Response Relationship, Radiation Helium Models, Biological Probability Protons Radiation, Ionizing* |
| Chemical | |
Reg. No./Substance:
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0/Protons; 7440-59-7/Helium; 7782-39-0/Deuterium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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