| Cell growth and size homeostasis in proliferating animal cells. | |
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MedLine Citation:
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PMID: 19589995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A long-standing question in biology is whether there is an intrinsic mechanism for coordinating growth and the cell cycle in metazoan cells. We examined cell size distributions in populations of lymphoblasts and applied a mathematical analysis to calculate how growth rates vary with both cell size and the cell cycle. Our results show that growth rate is size-dependent throughout the cell cycle. After initial growth suppression, there is a rapid increase in growth rate during the G1 phase, followed by a period of constant exponential growth. The probability of cell division varies independently with cell size and cell age. We conclude that proliferating mammalian cells have an intrinsic mechanism that maintains cell size. |
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Authors:
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Amit Tzur; Ran Kafri; Valerie S LeBleu; Galit Lahav; Marc W Kirschner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 325 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-10 Completed Date: 2009-07-22 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 167-71 Citation Subset: IM |
Affiliation:
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Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Cell Division Cell Enlargement* Cell Proliferation* Cell Size* G1 Phase Homeostasis Lymphocytes / cytology* Mathematical Concepts Mice Mitosis Probability Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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GM026875/GM/NIGMS NIH HHS; GM083303/GM/NIGMS NIH HHS; R01 GM026875-34/GM/NIGMS NIH HHS; R01 GM083303-02/GM/NIGMS NIH HHS |
| Comments/Corrections | |
Comment In:
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Science. 2009 Jul 10;325(5937):158-9
[PMID:
19589991
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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