Document Detail


Cell and gene therapy in Alzheimer's disease.
MedLine Citation:
PMID:  23320452     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Alzheimer's disease is a progressive neurological disorder characterized by the aggregation of two proteins, amyloid-β and hyperphosphorylated tau, and by neuronal and synaptic loss. Although some drugs have been shown to slow the progression of the disease, at present no treatment has been developed that can stop or reverse the progression of the pathology. Recently, new therapeutic strategies have been proposed for the treatment of the disease. Among these, the development of stem cells and gene modified cells is an especially promising therapeutic approach for Alzheimer's disease. In this review we highlight the experimental and preclinical studies that have been focused on stem cell-based and gene-modified cell based uses as potential therapies for Alzheimer's disease. The potential clinical applications are also discussed.
Authors:
Micaela Johanna Glat; Daniel Offen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Stem cells and development     Volume:  -     ISSN:  1557-8534     ISO Abbreviation:  Stem Cells Dev.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197107     Medline TA:  Stem Cells Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Tel Aviv University, Felsenstein Medical Research Center, FMRC, Rabin Medical Center, Campus Beilinson, Petah-Tikva , Israel, 49100, 972-39376277, 972-39376130, , Tel Aviv University, The Sagol School of Neuroscience , Ramat Aviv, Tel Aviv, Israel, 39040; micaglat@gmail.com.
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