Document Detail


Cell fusions in mammals.
MedLine Citation:
PMID:  18351375     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell fusions are important to fertilization, placentation, development of skeletal muscle and bone, calcium homeostasis and the immune defense system. Additionally, cell fusions participate in tissue repair and may be important to cancer development and progression. A large number of factors appear to regulate cell fusions, including receptors and ligands, membrane domain organizing proteins, proteases, signaling molecules and fusogenic proteins forming alpha-helical bundles that bring membranes close together. The syncytin family of proteins represent true fusogens and the founding member, syncytin-1, has been documented to be involved in fusions between placental trophoblasts, between cancer cells and between cancer cells and host cells. We review the literature with emphasis on the syncytin family and propose that syncytins may represent universal fusogens in primates and rodents, which work together with a number of other proteins to regulate the cell fusion machinery.
Authors:
Lars-Inge Larsson; Bolette Bjerregaard; Jan Fredrik Talts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-03-20
Journal Detail:
Title:  Histochemistry and cell biology     Volume:  129     ISSN:  0948-6143     ISO Abbreviation:  Histochem. Cell Biol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-07-23     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9506663     Medline TA:  Histochem Cell Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  551-61     Citation Subset:  IM    
Affiliation:
Anatomy and Cell Biology, IBHV, Faculty of Life Sciences, University of Copenhagen, Gronnegaardsvej 7, 1870 Frederiksberg C, Denmark. lail@life.ku.dk
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Fusion
Female
Gene Products, env / analysis*,  physiology
Humans
Immunohistochemistry
Mammals / metabolism*
Neoplasms / metabolism,  pathology
Placenta / cytology,  metabolism
Pregnancy
Pregnancy Proteins / analysis*,  physiology
Chemical
Reg. No./Substance:
0/Gene Products, env; 0/Pregnancy Proteins; 0/syncytin
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